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2.45 GHz microwave radiation impairs learning, memory, and hippocampal synaptic plasticity in the rat

2018 · Mixed · Low evidence

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MixedLow evidencePaper 1967

Rats exposed to 2.45 GHz microwave radiation (0.016 mW/cm2; whole-body SAR 0.017 W/kg) for 2 h/day for 40 days showed decreased learning and memory performance, reduced long-term potentiation induction and CA1 neuron excitability, and decreased neuronal densi…

Study snapshot

Publicationmanual · 2018
Study typeanimal
Reported directionMixed
Evidence ratingLow

Abstract

2.45 GHz microwave radiation impairs learning, memory, and hippocampal synaptic plasticity in the rat Karimi N, Bayat M, Haghani M, Saadi H, Ghazipour GR. 2.45 GHz microwave radiation impairs learning, memory, and hippocampal synaptic plasticity in the rat. Toxicol Ind Health. 2018 Oct 21:748233718798976. doi: 10.1177/0748233718798976 Abstract Microwave (MW) radiation has a close relationship with neurobehavioral disorders. Due to the widespread usage of MW radiation, especially in our homes, it is essential to investigate the direct effect of MW radiation on the central nervous system. Therefore, this study was carried out to determine the effect of MW radiation on memory and hippocampal synaptic plasticity. The rats were exposed to 2.45 GHz MW radiation (continuous wave with overall average power density of 0.016 mW/cm2 and overall average whole-body specific absorption rate value of 0.017 W/kg) for 2 h/day over a period of 40 days. Spatial learning and memory were tested by radial maze and passive avoidance tests. We evaluated the synaptic plasticity and hippocampal neuronal cells number by field potential recording and Giemsa staining, respectively. Our results showed that MW radiation exposure decreased the learning and memory performance that was associated with decrement of long-term potentiation induction and excitability of CA1 neurons. However, MW radiation did not have any effects on short-term plasticity and paired-pulse ratio as a good indirect index for measurement of glutamate release probability. The evaluation of hippocampal morphology indicated that the neuronal density in the hippocampal CA1 area was significantly decreased by MW. ncbi.nlm.nih.gov

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionmixed
PopulationRats
Sample sizeNot supplied
Exposuremicrowave · 2450 MHz · 0.017 W/kg · 2 h/day for 40 days
Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Rats exposed to 2.45 GHz microwave radiation (0.016 mW/cm2; whole-body SAR 0.017 W/kg) for 2 h/day for 40 days showed decreased learning and memory performance, reduced long-term potentiation induction and CA1 neuron excitability, and decreased neuronal density in hippocampal CA1. No effects were reported on short-term plasticity or paired-pulse ratio.

Outcomes measured

  • Spatial learning
  • Memory performance
  • Hippocampal synaptic plasticity (LTP induction)
  • CA1 neuron excitability
  • Short-term plasticity
  • Paired-pulse ratio (glutamate release probability index)
  • Hippocampal CA1 neuronal density/morphology

Limitations

  • Sample size not reported in provided abstract/metadata
  • Exposure source/context not specified beyond microwave radiation
  • Journal name not provided in metadata
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "microwave",
    "source": null,
    "frequency_mhz": 2450,
    "sar_wkg": 0.017,
    "duration": "2 h/day for 40 days"
  },
  "population": "Rats",
  "sample_size": null,
  "outcomes": [
    "Spatial learning",
    "Memory performance",
    "Hippocampal synaptic plasticity (LTP induction)",
    "CA1 neuron excitability",
    "Short-term plasticity",
    "Paired-pulse ratio (glutamate release probability index)",
    "Hippocampal CA1 neuronal density/morphology"
  ],
  "main_findings": "Rats exposed to 2.45 GHz microwave radiation (0.016 mW/cm2; whole-body SAR 0.017 W/kg) for 2 h/day for 40 days showed decreased learning and memory performance, reduced long-term potentiation induction and CA1 neuron excitability, and decreased neuronal density in hippocampal CA1. No effects were reported on short-term plasticity or paired-pulse ratio.",
  "effect_direction": "mixed",
  "limitations": [
    "Sample size not reported in provided abstract/metadata",
    "Exposure source/context not specified beyond microwave radiation",
    "Journal name not provided in metadata"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "2.45 GHz",
    "microwave radiation",
    "rats",
    "learning",
    "memory",
    "hippocampus",
    "synaptic plasticity",
    "long-term potentiation",
    "CA1",
    "neuronal density",
    "power density",
    "SAR"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1177/0748233718798976
PubMed: Not supplied

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