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Vm-related extracellular potentials observed in red blood cells

2021 · Unclear · Insufficient evidence

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UnclearInsufficient evidencePaper 1019

Using red blood cells, the authors report that membrane potential (Vm) is detectable beyond the cell surface and that modulating Vm produces quantifiable and consistent changes in extracellular potential. They report evidence suggesting capacitive coupling be…

Study snapshot

Publicationmanual · 2021
Study typeother
Reported directionUnclear
Evidence ratingInsufficient

Abstract

Vm-related extracellular potentials observed in red blood cells Hughes MP, Kruchek EJ, Beale AD, Kitcatt SJ, Qureshi S, Trott ZP, Charbonnel O, Agbaje PA, Henslee EA, Dorey RA, Lewis R, Labeed FH. Vm-related extracellular potentials observed in red blood cells. Sci Rep. 2021 Sep 30;11(1):19446. doi: 10.1038/s41598-021-98102-9. Abstract Even in nonexcitable cells, the membrane potential Vm is fundamental to cell function, with roles from ion channel regulation, development, to cancer metastasis. Vm arises from transmembrane ion concentration gradients; standard models assume homogeneous extracellular and intracellular ion concentrations, and that Vm only exists across the cell membrane and has no significance beyond it. Using red blood cells, we show that this is incorrect, or at least incomplete; Vm is detectable beyond the cell surface, and modulating Vm produces quantifiable and consistent changes in extracellular potential. Evidence strongly suggests this is due to capacitive coupling between Vm and the electrical double layer, rather than molecular transporters. We show that modulating Vm changes the extracellular ion composition, mimicking the behaviour if voltage-gated ion channels in non-excitable channels. We also observed Vm-synchronised circadian rhythms in extracellular potential, with significant implications for cell-cell interactions and cardiovascular disease. Open access paper: ncbi.nlm.nih.gov

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeother
Effect directionunclear
PopulationRed blood cells
Sample sizeNot supplied
ExposureNot supplied
Evidence strengthInsufficientConfidence: 74% · Peer reviewed: yes

Main findings

Using red blood cells, the authors report that membrane potential (Vm) is detectable beyond the cell surface and that modulating Vm produces quantifiable and consistent changes in extracellular potential. They report evidence suggesting capacitive coupling between Vm and the electrical double layer and observe Vm-synchronised circadian rhythms in extracellular potential.

Outcomes measured

  • Detection of extracellular potentials beyond the red blood cell surface related to membrane potential (Vm)
  • Changes in extracellular potential with Vm modulation
  • Changes in extracellular ion composition with Vm modulation
  • Vm-synchronised circadian rhythms in extracellular potential
View raw extracted JSON
{
  "study_type": "other",
  "exposure": {
    "band": null,
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Red blood cells",
  "sample_size": null,
  "outcomes": [
    "Detection of extracellular potentials beyond the red blood cell surface related to membrane potential (Vm)",
    "Changes in extracellular potential with Vm modulation",
    "Changes in extracellular ion composition with Vm modulation",
    "Vm-synchronised circadian rhythms in extracellular potential"
  ],
  "main_findings": "Using red blood cells, the authors report that membrane potential (Vm) is detectable beyond the cell surface and that modulating Vm produces quantifiable and consistent changes in extracellular potential. They report evidence suggesting capacitive coupling between Vm and the electrical double layer and observe Vm-synchronised circadian rhythms in extracellular potential.",
  "effect_direction": "unclear",
  "limitations": [],
  "evidence_strength": "insufficient",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "membrane potential",
    "Vm",
    "extracellular potential",
    "red blood cells",
    "capacitive coupling",
    "electrical double layer",
    "extracellular ion composition",
    "circadian rhythms",
    "cell-cell interactions",
    "cardiovascular disease"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1038/s41598-021-98102-9
PubMed: Not supplied

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