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Decreased Level of Plasma nesfatin-1 in Rats Exposed to Cell Phone Radiation Is Correlated With Thyroid Dysfunction, Oxidative Stress, and Apoptosis

Archives of physiology and biochemistry · 2020 · Harm · Low evidence

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HarmLow evidencePaper 1504

After 30 days, rats exposed to cell phone electromagnetic radiation fields showed significantly decreased plasma nesfatin-1 levels and decreased thyroid function, with increased oxidative stress and apoptosis in thyroid tissue. Nesfatin-1 levels were reported…

Study snapshot

PublicationArchives of physiology and biochemistry · 2020
Study typeanimal
Reported directionHarm
Evidence ratingLow

Abstract

Decreased Level of Plasma nesfatin-1 in Rats Exposed to Cell Phone Radiation Is Correlated With Thyroid Dysfunction, Oxidative Stress, and Apoptosis Noha I Hussien, Ayman M Mousa, Abeer A Shoman. Decreased Level of Plasma nesfatin-1 in Rats Exposed to Cell Phone Radiation Is Correlated With Thyroid Dysfunction, Oxidative Stress, and Apoptosis Arch Physiol Biochem. 2020 Jun 17;1-7. doi: 10.1080/13813455.2020.1778037. Abstract Context: Exposure to Electomagnetic radiation fields of cell phones causes thyroid dysfunction and a previous study revealed that nesfatin-1 may affect functions of the thyroid gland. Objective: To study the role of nesfatin-1 on functions of rat's thyroid gland exposed to EMRF. Materials and methods: Thirty adult male rats were divided equally into 3 groups as group I, group II and group III. The experiment extended for 30 days then the plasma nesfatin-1 level, thyroid functions, and thyroid tissue oxidative stress were assessed. Also; histological and immunohistochemical study studies were done to evaluate structural and apoptotic changes of the thyroid gland. Results: There was a significant decrease in plasma nesfatin-1 level and thyroid functions with an increase in oxidative stress and apoptosis. Interestingly, there was a correlation between nesfatin-1 level and markers of thyroid function, oxidative stress and apoptosis. Conclusion: Nesfatin-1 plays a role in thyroid dysfunctions of rats exposed to mobile phone radiation. pubmed.ncbi.nlm.nih.gov

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionharm
PopulationThirty adult male rats
Sample size30
ExposureRF · 30 days
Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

After 30 days, rats exposed to cell phone electromagnetic radiation fields showed significantly decreased plasma nesfatin-1 levels and decreased thyroid function, with increased oxidative stress and apoptosis in thyroid tissue. Nesfatin-1 levels were reported to correlate with markers of thyroid function, oxidative stress, and apoptosis.

Outcomes measured

  • Plasma nesfatin-1 level
  • Thyroid function
  • Thyroid tissue oxidative stress
  • Thyroid gland histological changes
  • Thyroid gland apoptotic changes

Limitations

  • Exposure parameters (e.g., frequency, SAR, intensity) not reported in the abstract
  • Only adult male rats were studied
  • Group-specific details of exposure/control conditions are not described in the abstract
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": "mobile phone",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "30 days"
  },
  "population": "Thirty adult male rats",
  "sample_size": 30,
  "outcomes": [
    "Plasma nesfatin-1 level",
    "Thyroid function",
    "Thyroid tissue oxidative stress",
    "Thyroid gland histological changes",
    "Thyroid gland apoptotic changes"
  ],
  "main_findings": "After 30 days, rats exposed to cell phone electromagnetic radiation fields showed significantly decreased plasma nesfatin-1 levels and decreased thyroid function, with increased oxidative stress and apoptosis in thyroid tissue. Nesfatin-1 levels were reported to correlate with markers of thyroid function, oxidative stress, and apoptosis.",
  "effect_direction": "harm",
  "limitations": [
    "Exposure parameters (e.g., frequency, SAR, intensity) not reported in the abstract",
    "Only adult male rats were studied",
    "Group-specific details of exposure/control conditions are not described in the abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "nesfatin-1",
    "mobile phone radiation",
    "electromagnetic radiation fields",
    "thyroid dysfunction",
    "oxidative stress",
    "apoptosis",
    "rats"
  ],
  "suggested_hubs": [
    {
      "slug": "mobile-phones",
      "weight": 0.9,
      "reason": "Study examines effects of cell phone radiation exposure."
    }
  ]
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1080/13813455.2020.1778037
PubMed: 32552170

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