Static electric field inhibits the proliferation and secretion functions of splenic lymphocytes in mice

International journal of environmental health research · 2023 · Harm · Low evidence

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HarmLow evidencePaper 510

Study snapshot

PublicationInternational journal of environmental health research · 2023

Study typeanimal

Reported directionHarm

Evidence ratingLow

Abstract

Static electric field inhibits the proliferation and secretion functions of splenic lymphocytes in mice Dong L, Wu J, Di G. Static electric field inhibits the proliferation and secretion functions of splenic lymphocytes in mice. Int J Environ Health Res. 2023 Apr 18:1-11. doi: 10.1080/09603123.2023.2202900. Abstract In recent years, the effects of static electric field (SEF) generated by ultra-high voltage (UHV) direct current (DC) transmission lines on health has drawn public attention. To study the effects of SEF on the spleen, mice were exposed to 56.3 ± 1.4 kV/m SEF. Results showed that on the 28th day of SEF exposure, the contents of IL-10 and IFN-γ in the supernatant of homogenate, the proliferation levels of lymphocytes and the content of intracellular ROS decreased significantly, while the activity of SOD increased significantly. Meanwhile, the rupture of cellular membrane, the deficiency of mitochondrial cristae and the vacuolization of mitochondria appeared in lymphocytes. Analysis showed that the rupture of the cellular membrane caused the death of T lymphocytes, which would lead to the reduction of IL-10 and IFN-γ secretions. The damage of mitochondria could reduce the production of ATP and the content of ROS, which could inhibit the proliferation of splenic lymphocytes. pubmed.ncbi.nlm.nih.gov

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionharm

PopulationMice (splenic lymphocytes)

Sample sizeNot supplied

Exposureother · 28 days

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Mice exposed to a 56.3 ± 1.4 kV/m static electric field showed, on day 28, significantly decreased IL-10 and IFN-γ in spleen homogenate supernatant, decreased lymphocyte proliferation, and decreased intracellular ROS, with significantly increased SOD activity. Lymphocytes showed membrane rupture and mitochondrial structural damage; the authors attribute reduced cytokine secretion to T-lymphocyte death and reduced proliferation to mitochondrial damage affecting ATP/ROS.

Outcomes measured

IL-10 content
IFN-γ content
splenic lymphocyte proliferation
intracellular ROS content
SOD activity
lymphocyte cellular membrane integrity
mitochondrial ultrastructure (cristae deficiency, vacuolization)
ATP production (inferred as discussed)

Limitations

Sample size not reported in the provided abstract.
Only one exposure level is described in the abstract.
Outcome timing emphasized at day 28; earlier timepoints not described in the abstract.
Findings are from a mouse model; human relevance is not established in the abstract.

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "other",
    "source": "ultra-high voltage (UHV) direct current (DC) transmission lines",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "28 days"
  },
  "population": "Mice (splenic lymphocytes)",
  "sample_size": null,
  "outcomes": [
    "IL-10 content",
    "IFN-γ content",
    "splenic lymphocyte proliferation",
    "intracellular ROS content",
    "SOD activity",
    "lymphocyte cellular membrane integrity",
    "mitochondrial ultrastructure (cristae deficiency, vacuolization)",
    "ATP production (inferred as discussed)"
  ],
  "main_findings": "Mice exposed to a 56.3 ± 1.4 kV/m static electric field showed, on day 28, significantly decreased IL-10 and IFN-γ in spleen homogenate supernatant, decreased lymphocyte proliferation, and decreased intracellular ROS, with significantly increased SOD activity. Lymphocytes showed membrane rupture and mitochondrial structural damage; the authors attribute reduced cytokine secretion to T-lymphocyte death and reduced proliferation to mitochondrial damage affecting ATP/ROS.",
  "effect_direction": "harm",
  "limitations": [
    "Sample size not reported in the provided abstract.",
    "Only one exposure level is described in the abstract.",
    "Outcome timing emphasized at day 28; earlier timepoints not described in the abstract.",
    "Findings are from a mouse model; human relevance is not established in the abstract."
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "static electric field",
    "SEF",
    "direct current",
    "UHV transmission lines",
    "mice",
    "splenic lymphocytes",
    "IL-10",
    "IFN-γ",
    "ROS",
    "SOD",
    "mitochondria",
    "immune function"
  ],
  "suggested_hubs": [
    {
      "slug": "occupational-exposure",
      "weight": 0.35,
      "reason": "Exposure source discussed as fields generated by UHV DC transmission lines, relevant to environmental/occupational contexts."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1080/09603123.2023.2202900
PubMed: 37070850

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