Effect of mobile phone radiation on pentylenetetrazole-induced seizure threshold in mice

Iran J Basic Med Sci · 2016 · Harm · Low evidence

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HarmLow evidencePaper 6913

Acute exposure to 900–950 MHz mobile phone radiation did not change seizure threshold. Chronic exposure significantly decreased clonic and tonic seizure thresholds.

Study snapshot

PublicationIran J Basic Med Sci · 2016

Study typeanimal

Reported directionHarm

Evidence ratingLow

Abstract

Objectives: Scientific interest in potential mobile phone impact on human brain and performance has significantly increased in recent years. The present study was designed to evaluate the effects of mobile phone radiation on seizure threshold in mice. Materials and methods: BALB/c male mice were randomly divided into three groups: control, acute, and chronic mobile phone radiation for 30, 60, and 90 min with frequency 900 to 950 MHz and pulse of 217 Hz. The chronic group received 30 days of radiation, while the acute group received only once. The intravenous infusion of pentylenetetrazole (5 mg/ml) was used to induce seizure signs. Results: Although acute mobile radiation did not change seizure threshold, chronic radiation decreased the clonic and tonic seizure thresholds significantly. Conclusion: Our data suggests that the continued and prolonged contact with the mobile phone radiation might increase the risk of seizure attacks and should be limited.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionharm

PopulationMale BALB/c mice

Sample sizeNot supplied

ExposureRF · Acute exposure once or chronic exposure for 30 days; exposure sessions were 30, 60, or 90 minutes.

Evidence strengthLowConfidence: 98% · Peer reviewed: yes

Main findings

Acute exposure to 900–950 MHz mobile phone radiation did not change seizure threshold. Chronic exposure significantly decreased clonic and tonic seizure thresholds.

Outcomes measured

Pentylenetetrazole-induced clonic seizure threshold
Pentylenetetrazole-induced tonic seizure threshold

Limitations

Animal study; applicability to humans is not established by the abstract.
Sample size was not reported in the abstract.
Specific absorption rate was not reported in the abstract.

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": "mobile phone",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "Acute exposure once or chronic exposure for 30 days; exposure sessions were 30, 60, or 90 minutes."
  },
  "population": "Male BALB/c mice",
  "sample_size": null,
  "outcomes": [
    "Pentylenetetrazole-induced clonic seizure threshold",
    "Pentylenetetrazole-induced tonic seizure threshold"
  ],
  "main_findings": "Acute exposure to 900–950 MHz mobile phone radiation did not change seizure threshold. Chronic exposure significantly decreased clonic and tonic seizure thresholds.",
  "effect_direction": "harm",
  "limitations": [
    "Animal study; applicability to humans is not established by the abstract.",
    "Sample size was not reported in the abstract.",
    "Specific absorption rate was not reported in the abstract."
  ],
  "evidence_strength": "low",
  "confidence": 0.98,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "mobile phone radiation",
    "radiofrequency",
    "900–950 MHz",
    "seizure threshold",
    "pentylenetetrazole",
    "BALB/c mice",
    "chronic exposure",
    "acute exposure"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 27635206

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