Maternal linalool treatment protects against radiofrequency wave-induced deteriorations in

Scientific Reports · 2024 · Mixed · Low evidence

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MixedLow evidencePaper 100

Study snapshot

PublicationScientific Reports · 2024

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

Maternal linalool treatment protects against radiofrequency wave-induced deteriorations in adolescent rats: A behavioral and electrophysiological study Azimzadeh M, Noorbakhshnia M. Maternal linalool treatment protects against radiofrequency wave- induced deteriorations in adolescent rats: A behavioral and electrophysiological study. Sci Rep. 2024 Jul 27;14(1):17257. doi: 10.1038/s41598-024-68103-5. Abstract Recent years, the rapid advancement of technology has raised concerns. We studied the effects of prenatal exposure to 900 MHz radiofrequency (RF) from mobile phones and the protective effects of linalool on learning and memory, and anxiety in adolescent male and female offspring rats. Pregnant rats were divided into four groups: control, wave, wave + linalool, and linalool. Rats received linalool (25mg/kg) by gavage for 21 days. Irradiation was conducted from day 0 to day 21 of pregnancy. Offsprings underwent behavioral and electrophysiological tests on days 50 and 60 after birth. Exposure to RF during pregnancy caused anxiety-like behavior in the EPM test and impairment of learning and memory in the Morris water maze and shuttle box tests. Electrophysiological properties and synaptic plasticity of the dorsal hippocampal CA3-CA1 synapse showed a decrease in fEPSP amplitude and slope. The trace element levels in both male and female offspring were consistent across all groups compared to their respective controls. In the hippocampus tissue, the levels of Fe, Cu, and Mn, as well as the Cu/Zn ratio, were significantly higher in the exposed groups (wave groups) compared to their controls. Moreover, Zn levels were significantly lower in the hippocampus tissue of the exposed groups. Linalool administration mitigated the excessive increase in Fe, Cu, Mn, and Cu/Zn ratio and normalized the disrupted levels of trace elements, except for Zn levels in both male and female offspring. Sex differences were observed in the EPM and shuttle box tests, females were more sensitive than males. In summary, our study demonstrates that prenatal exposure to mobile phone radiation induces stress-like behaviors, disrupts learning and memory, alters hippocampal electrophysiological properties and trace element balance in offspring. Treatment with linalool mitigates these deleterious effects, highlighting its potential as a therapeutic intervention. These findings contribute to our understanding of the impact of prenatal environmental exposures on neurodevelopment and offer insights into potential strategies for neuroprotection. nature.com

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionmixed

PopulationPregnant rats and adolescent male and female offspring rats

Sample sizeNot supplied

ExposureRF · 900 MHz · Gestational day 0 to day 21 (prenatal exposure); offspring tested postnatally on days 50 and 60

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Prenatal 900 MHz RF exposure during pregnancy was associated with anxiety-like behavior and impaired learning/memory in offspring, along with decreased fEPSP amplitude and slope at the dorsal hippocampal CA3-CA1 synapse. Hippocampal Fe, Cu, Mn and Cu/Zn ratio were higher and Zn was lower in exposed groups; maternal linalool treatment mitigated several of these changes (except Zn) and reduced behavioral/electrophysiological deteriorations.

Outcomes measured

Anxiety-like behavior (EPM test)
Learning and memory (Morris water maze, shuttle box)
Hippocampal electrophysiology/synaptic plasticity (dorsal hippocampal CA3-CA1; fEPSP amplitude and slope)
Trace element levels (Fe, Cu, Mn, Zn; Cu/Zn ratio) in hippocampus tissue and in offspring

Limitations

Sample size not reported in provided abstract/metadata
Exposure intensity/dosimetry (e.g., SAR) not reported in provided abstract/metadata
Animal model; generalizability to humans is uncertain

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": "mobile phone",
    "frequency_mhz": 900,
    "sar_wkg": null,
    "duration": "Gestational day 0 to day 21 (prenatal exposure); offspring tested postnatally on days 50 and 60"
  },
  "population": "Pregnant rats and adolescent male and female offspring rats",
  "sample_size": null,
  "outcomes": [
    "Anxiety-like behavior (EPM test)",
    "Learning and memory (Morris water maze, shuttle box)",
    "Hippocampal electrophysiology/synaptic plasticity (dorsal hippocampal CA3-CA1; fEPSP amplitude and slope)",
    "Trace element levels (Fe, Cu, Mn, Zn; Cu/Zn ratio) in hippocampus tissue and in offspring"
  ],
  "main_findings": "Prenatal 900 MHz RF exposure during pregnancy was associated with anxiety-like behavior and impaired learning/memory in offspring, along with decreased fEPSP amplitude and slope at the dorsal hippocampal CA3-CA1 synapse. Hippocampal Fe, Cu, Mn and Cu/Zn ratio were higher and Zn was lower in exposed groups; maternal linalool treatment mitigated several of these changes (except Zn) and reduced behavioral/electrophysiological deteriorations.",
  "effect_direction": "mixed",
  "limitations": [
    "Sample size not reported in provided abstract/metadata",
    "Exposure intensity/dosimetry (e.g., SAR) not reported in provided abstract/metadata",
    "Animal model; generalizability to humans is uncertain"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "prenatal exposure",
    "900 MHz",
    "radiofrequency",
    "mobile phone radiation",
    "linalool",
    "anxiety",
    "learning and memory",
    "Morris water maze",
    "shuttle box",
    "EPM",
    "hippocampus",
    "fEPSP",
    "synaptic plasticity",
    "trace elements",
    "Fe",
    "Cu",
    "Mn",
    "Zn"
  ],
  "suggested_hubs": [
    {
      "slug": "mobile-phones-rf",
      "weight": 0.9,
      "reason": "Study examines prenatal exposure to 900 MHz RF from mobile phones and neurobehavioral/electrophysiological outcomes in offspring."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1038/s41598-024-68103-5
PubMed: Not supplied

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