Increased mobility and stem-cell proliferation rate in Dugesia tigrina induced by 880nm light emitting diode

J Photochem Photobiol B · 2011 · Benefit · Low evidence

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BenefitLow evidencePaper 6828

Amputated planarian exposed to near-infrared 880 nm LED light showed increased mobility by the 3rd day of exposure compared with other lighting conditions. Higher stem-cell densities were also measured 84 hours post-injury in the near-infrared group.

Study snapshot

PublicationJ Photochem Photobiol B · 2011

Study typeanimal

Reported directionBenefit

Evidence ratingLow

Abstract

The therapeutic effects elicited by photobiostimulation in the near infrared range may be associated with increased proliferation rate of particular cell-types. The present study utilized commercial light emitting diodes to investigate the effects of low-level near-infrared radiation on the proliferation rate of stem cells in amputated planarian. Whole and amputated animals were exposed to either ambient diurnal lighting, darkness, white light, red light, or near-infrared (880 nm) light. Irradiation was consistent for the duration of the experiments and was provided using commercial 5mm light emitting diodes (∼1.0 mW/m(2) in power density and ∼0.01 J/cm(2) in radiant exposure). Compared to other groups amputated planarian exposed to near-infrared displayed increased mobility by the 3rd day of exposure (F((4,26))=4.31, p<0.04, η(2)=41%). Higher densities of stem cells were measured in these worms 84 h post injury (F((4,72))=4.78, p<0.01, η(2)=21%). These findings suggest that non-coherent light sources with power-densities about 1000 times lower than contemporary low-power laser settings remain effective in generating photobiostimulation effects and warrants further investigation on stem-cell proliferation induced by near-infrared light emitting diodes.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionbenefit

PopulationWhole and amputated planarian (Dugesia tigrina)

Sample sizeNot supplied

Exposureother · Consistent irradiation for the duration of the experiments; effects reported by day 3 and 84 h post-injury

Evidence strengthLowConfidence: 94% · Peer reviewed: yes

Main findings

Outcomes measured

Mobility
Stem-cell density/proliferation rate

Limitations

Animal study
Sample size not stated in the abstract
Exposure was near-infrared light rather than EMF exposures typically classified as ELF/RF
Abstract does not report detailed quantitative results for all comparison groups

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "other",
    "source": "other",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "Consistent irradiation for the duration of the experiments; effects reported by day 3 and 84 h post-injury"
  },
  "population": "Whole and amputated planarian (Dugesia tigrina)",
  "sample_size": null,
  "outcomes": [
    "Mobility",
    "Stem-cell density/proliferation rate"
  ],
  "main_findings": "Amputated planarian exposed to near-infrared 880 nm LED light showed increased mobility by the 3rd day of exposure compared with other lighting conditions. Higher stem-cell densities were also measured 84 hours post-injury in the near-infrared group.",
  "effect_direction": "benefit",
  "limitations": [
    "Animal study",
    "Sample size not stated in the abstract",
    "Exposure was near-infrared light rather than EMF exposures typically classified as ELF/RF",
    "Abstract does not report detailed quantitative results for all comparison groups"
  ],
  "evidence_strength": "low",
  "confidence": 0.94,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "near-infrared",
    "880 nm",
    "LED",
    "photobiostimulation",
    "planarian",
    "Dugesia tigrina",
    "stem cells",
    "mobility",
    "animal study"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1016/j.jphotobiol.2010.11.003
PubMed: 21146998

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