Age-dependent effect of long-term microwave radiation on postnatal neurogenesis in rats: morphological and behavioral study.

Physiological research · 2018 · Harm · Low evidence

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HarmLow evidencePaper 6625

Study snapshot

PublicationPhysiological research · 2018

Study typeanimal

Reported directionHarm

Evidence ratingLow

Abstract

Processes of adult neurogenesis can be influenced by environmental factors. Here, we investigated the effect of microwave radiation (MWR) on proliferation and cell dying in the rat rostral migratory stream (RMS) - a migration route for the neuroblasts of the subventricular zone. Adult and juvenile (two weeks old) rats were exposed to a pulsed-wave MWR at the frequency of 2.45 GHz for 1 or 3 h daily during 3 weeks. Adult rats were divided into two groups: without survival and with two weeks survival after irradiation. Juvenile rats survived till adulthood, when were tested in the light/dark test. Proliferating cells in the RMS were labeled by Ki-67; dying cells were visualized by Fluoro-Jade C histochemistry. In both groups of rats irradiated as adults we have observed significant decrease of the number of dividing cells within the RMS. Exposure of juvenile rats to MWR induced only slight decrease in proliferation, however, it strikingly affected cell death even two months following irradiation. In addition, these rats displayed locomotor hyperactivity and decreased risk assessment in adulthood. Our results suggest that the long-lasting influence of radiation is manifested by affected cell survival and changes in animals´ behavior.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionharm

PopulationRats (adult and juvenile, two weeks old)

Sample sizeNot supplied

Exposuremicrowave · 2450 MHz · 1 or 3 h daily during 3 weeks

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Adult rats exposed to pulsed-wave 2.45 GHz microwave radiation showed a significant decrease in the number of dividing (Ki-67+) cells in the rostral migratory stream. Juvenile exposure produced only a slight decrease in proliferation but markedly affected cell death even two months after irradiation, and was associated with locomotor hyperactivity and decreased risk assessment in adulthood.

Outcomes measured

Postnatal/adult neurogenesis (cell proliferation in rostral migratory stream; Ki-67)
Cell death in rostral migratory stream (Fluoro-Jade C)
Behavior in adulthood (light/dark test; locomotor activity; risk assessment)

Limitations

Sample size not reported in the provided abstract/metadata
Exposure intensity/SAR not reported
Details of sham/control conditions not described in the provided abstract
Behavioral testing described briefly; limited methodological detail in abstract

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "microwave",
    "source": null,
    "frequency_mhz": 2450,
    "sar_wkg": null,
    "duration": "1 or 3 h daily during 3 weeks"
  },
  "population": "Rats (adult and juvenile, two weeks old)",
  "sample_size": null,
  "outcomes": [
    "Postnatal/adult neurogenesis (cell proliferation in rostral migratory stream; Ki-67)",
    "Cell death in rostral migratory stream (Fluoro-Jade C)",
    "Behavior in adulthood (light/dark test; locomotor activity; risk assessment)"
  ],
  "main_findings": "Adult rats exposed to pulsed-wave 2.45 GHz microwave radiation showed a significant decrease in the number of dividing (Ki-67+) cells in the rostral migratory stream. Juvenile exposure produced only a slight decrease in proliferation but markedly affected cell death even two months after irradiation, and was associated with locomotor hyperactivity and decreased risk assessment in adulthood.",
  "effect_direction": "harm",
  "limitations": [
    "Sample size not reported in the provided abstract/metadata",
    "Exposure intensity/SAR not reported",
    "Details of sham/control conditions not described in the provided abstract",
    "Behavioral testing described briefly; limited methodological detail in abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "microwave radiation",
    "2.45 GHz",
    "pulsed-wave",
    "rat",
    "rostral migratory stream",
    "neurogenesis",
    "Ki-67",
    "Fluoro-Jade C",
    "cell death",
    "behavior",
    "light/dark test",
    "locomotor hyperactivity"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.33549/physiolres.933752
PubMed: 29527915

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