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[The state of receptor-dependent signal pathways in the agranulocytes from the peripheral blood of the reconvalescent patients following community-acquired pneumonia under the influence of microwave radiation].

Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury · 2016 · Mixed · Very low evidence

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MixedVery low evidencePaper 6593

In a whole blood cell culture model from reconvalescent patients after community-acquired bacterial pneumonia, exposure to 1000 MHz electromagnetic radiation (power flux density 0.1 mcW/cm2) was associated with increased intracellular concentrations of Janus …

Study snapshot

PublicationVoprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury · 2016
Study typein_vitro
Reported directionMixed
Evidence ratingVery low

Abstract

The present article reports the study of the influence of low-intensity microwave radiation on the state of the JAK/STAT-signaling pathways in the mononuclear cells and the intercellular levels of the molecules maintaining the functioning of this pathway. The experiments on the model of intercellular interactions in the whole blood cell culture obtained during the convalescence phase of community-acquired bacterial pneumonia were designed to elucidate the effects of the cell-cell interactions in the culture exposed to electromagnetic radiation with a frequency of 1000 MHz and power flux density 0.1 mcW/cm2 on the intracellular levels of total and phosphorylated species of JAK-kinases, STAT-factors and SOCS-proteins. It is concluded that sensitivity of intracellular signaling systems to the effects of low-intensity microwave radiation manifests itself in the form of increased intracellular concentrations of Janus kinases and SOCS proteins with a simultaneous decrease in the level of STAT factors.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro
Effect directionmixed
PopulationWhole blood cell culture obtained during convalescence phase of community-acquired bacterial pneumonia (reconvalescent patients)
Sample sizeNot supplied
Exposuremicrowave · 1000 MHz
Evidence strengthVery lowConfidence: 74% · Peer reviewed: yes

Main findings

In a whole blood cell culture model from reconvalescent patients after community-acquired bacterial pneumonia, exposure to 1000 MHz electromagnetic radiation (power flux density 0.1 mcW/cm2) was associated with increased intracellular concentrations of Janus kinases and SOCS proteins and a simultaneous decrease in STAT factor levels.

Outcomes measured

  • Intracellular levels of total and phosphorylated JAK kinases
  • Intracellular levels of STAT factors
  • Intracellular levels of SOCS proteins

Limitations

  • Sample size not reported in abstract
  • Exposure duration not reported in abstract
  • In vitro whole blood cell culture model; clinical relevance not established in abstract
View raw extracted JSON
{
  "study_type": "in_vitro",
  "exposure": {
    "band": "microwave",
    "source": null,
    "frequency_mhz": 1000,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Whole blood cell culture obtained during convalescence phase of community-acquired bacterial pneumonia (reconvalescent patients)",
  "sample_size": null,
  "outcomes": [
    "Intracellular levels of total and phosphorylated JAK kinases",
    "Intracellular levels of STAT factors",
    "Intracellular levels of SOCS proteins"
  ],
  "main_findings": "In a whole blood cell culture model from reconvalescent patients after community-acquired bacterial pneumonia, exposure to 1000 MHz electromagnetic radiation (power flux density 0.1 mcW/cm2) was associated with increased intracellular concentrations of Janus kinases and SOCS proteins and a simultaneous decrease in STAT factor levels.",
  "effect_direction": "mixed",
  "limitations": [
    "Sample size not reported in abstract",
    "Exposure duration not reported in abstract",
    "In vitro whole blood cell culture model; clinical relevance not established in abstract"
  ],
  "evidence_strength": "very_low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "microwave radiation",
    "1000 MHz",
    "power flux density",
    "whole blood cell culture",
    "community-acquired pneumonia",
    "convalescence",
    "JAK/STAT",
    "Janus kinases",
    "STAT",
    "SOCS",
    "intracellular signaling"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.17116/kurort2016323-28
PubMed: 27271829

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