RF Safe

GSM 900 MHz Microwave Radiation-Induced Alterations of Insulin Level and Histopathological Changes of Liver and Pancreas in Rat.

Journal of biomedical physics & engineering · 2016 · Mixed · Low evidence

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MixedLow evidencePaper 6584

In this rat study (SAR 2.0 W/kg), GSM 900 MHz exposure for 7 days did not alter insulin release compared with sham. Histopathology showed mild to severe inflammatory changes in liver portal spaces and damage in islet of Langerhans cells, with changes linked t…

Study snapshot

PublicationJournal of biomedical physics & engineering · 2016
Study typeanimal
Reported directionMixed
Evidence ratingLow

Abstract

BACKGROUND: The rapidly increasing use of mobile phones has led to public concerns about possible health effects of these popular communication devices. This study is an attempt to investigate the effects of radiofrequency (RF) radiation produced by GSM mobile phones on the insulin release in rats. METHODS: Forty two female adult Sprague Dawley rats were randomly divided into 4 groups. Group1 were exposed to RF radiation 6 hours per day for 7 days. Group 2 received sham exposure (6 hours per day for 7 days). Groups 3 and 4 received RF radiation 3 hours per day for 7 days and sham exposure (3 hours per day), respectively. The specific absorption rate (SAR) of RF was 2.0 W/kg. RESULTS: Our results showed that RF radiations emitted from mobile phone could not alter insulin release in rats. However, mild to severe inflammatory changes in the portal spaces of the liver of rats as well as damage in the cells of islet of Langerhans were observed. These changes were linked with the duration of the exposures. CONCLUSION: RF exposure can induce inflammatory changes in the liver as well causing damage in the cells of islet of Langerhans.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionmixed
PopulationFemale adult Sprague Dawley rats
Sample size42
ExposureRF · 900 MHz · 2 W/kg · 3 or 6 hours/day for 7 days
Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

In this rat study (SAR 2.0 W/kg), GSM 900 MHz exposure for 7 days did not alter insulin release compared with sham. Histopathology showed mild to severe inflammatory changes in liver portal spaces and damage in islet of Langerhans cells, with changes linked to exposure duration.

Outcomes measured

  • Insulin release/insulin level
  • Histopathological changes in liver (inflammatory changes in portal spaces)
  • Histopathological changes in pancreas (islet of Langerhans cell damage)

Limitations

  • No quantitative insulin results or statistical details reported in the abstract
  • Exposure characterization beyond frequency and SAR (e.g., dosimetry details) not described in the abstract
  • Short exposure period (7 days)
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": "mobile phone",
    "frequency_mhz": 900,
    "sar_wkg": 2,
    "duration": "3 or 6 hours/day for 7 days"
  },
  "population": "Female adult Sprague Dawley rats",
  "sample_size": 42,
  "outcomes": [
    "Insulin release/insulin level",
    "Histopathological changes in liver (inflammatory changes in portal spaces)",
    "Histopathological changes in pancreas (islet of Langerhans cell damage)"
  ],
  "main_findings": "In this rat study (SAR 2.0 W/kg), GSM 900 MHz exposure for 7 days did not alter insulin release compared with sham. Histopathology showed mild to severe inflammatory changes in liver portal spaces and damage in islet of Langerhans cells, with changes linked to exposure duration.",
  "effect_direction": "mixed",
  "limitations": [
    "No quantitative insulin results or statistical details reported in the abstract",
    "Exposure characterization beyond frequency and SAR (e.g., dosimetry details) not described in the abstract",
    "Short exposure period (7 days)"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "GSM",
    "900 MHz",
    "radiofrequency",
    "mobile phone",
    "SAR 2.0 W/kg",
    "rat",
    "insulin",
    "liver",
    "pancreas",
    "islet of Langerhans",
    "histopathology",
    "inflammation"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 28144593

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