Detection of microwave radiation of cytochrome CYP102 A1 solution during the enzyme reaction.

Biochemistry and biophysics reports · 2016 · Unclear · Very low evidence

← Research stream

UnclearVery low evidencePaper 6567

Microwave radiation at 3.4–4.2 GHz from a cytochrome P450 CYP102 A1 (BM3) solution was registered during lauric acid hydroxylation. Radiation generation was reported to occur after addition of NADPH to a system containing enzyme and substrate, and was observe…

Study snapshot

PublicationBiochemistry and biophysics reports · 2016

Study typein_vitro

Reported directionUnclear

Evidence ratingVery low

Abstract

Microwave radiation at 3.4-4.2 GHz frequency of the cytochrome P450 CYP102 A1 (BM3) solution was registered during the lauric acid hydroxylation reaction. The microwave radiation generation was shown to occur following the addition of electron donor NADPH to a system containing an enzyme and a substrate. The radiation occurs for the enzyme solutions with enzyme concentrations of 10 and 10 М. The microwave radiation effect elicited by the aqueous enzyme solution was observed for the first time. The results obtained can be used to elaborate a new approach to enzyme systems research, including studying of the mechanism of interaction of a functioning enzyme system with microenvironment.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro

Effect directionunclear

PopulationNot supplied

Sample sizeNot supplied

Exposuremicrowave

Evidence strengthVery lowConfidence: 66% · Peer reviewed: yes

Main findings

Outcomes measured

Microwave radiation detected from cytochrome P450 CYP102 A1 (BM3) solution during lauric acid hydroxylation reaction
Timing of radiation generation following NADPH addition
Radiation observed at enzyme concentrations of 10 and 10 M (as stated)

Limitations

No sample size or replication details provided in the abstract
Exposure/dosimetry metrics (e.g., power density, SAR) not reported
Enzyme concentration units/values appear unclear as written in the abstract

View raw extracted JSON

{
  "study_type": "in_vitro",
  "exposure": {
    "band": "microwave",
    "source": "other",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": null,
  "sample_size": null,
  "outcomes": [
    "Microwave radiation detected from cytochrome P450 CYP102 A1 (BM3) solution during lauric acid hydroxylation reaction",
    "Timing of radiation generation following NADPH addition",
    "Radiation observed at enzyme concentrations of 10 and 10 M (as stated)"
  ],
  "main_findings": "Microwave radiation at 3.4–4.2 GHz from a cytochrome P450 CYP102 A1 (BM3) solution was registered during lauric acid hydroxylation. Radiation generation was reported to occur after addition of NADPH to a system containing enzyme and substrate, and was observed for enzyme solutions at the stated concentrations.",
  "effect_direction": "unclear",
  "limitations": [
    "No sample size or replication details provided in the abstract",
    "Exposure/dosimetry metrics (e.g., power density, SAR) not reported",
    "Enzyme concentration units/values appear unclear as written in the abstract"
  ],
  "evidence_strength": "very_low",
  "confidence": 0.66,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "microwave radiation",
    "3.4-4.2 GHz",
    "cytochrome P450",
    "CYP102 A1",
    "BM3",
    "NADPH",
    "lauric acid hydroxylation",
    "enzyme reaction",
    "in vitro"
  ],
  "suggested_hubs": []
}

AI can be wrong. Always verify against the paper.

AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1016/j.bbrep.2015.12.013
PubMed: 28955835

Read the original paper →

Related papers

← Back to the Research Library