The influence of differently polarised microwave radiation on chromatin in human cells.

International journal of radiation biology · 2009 · Harm · Low evidence

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HarmLow evidencePaper 6493

Study snapshot

PublicationInternational journal of radiation biology · 2009

Study typeother

Reported directionHarm

Evidence ratingLow

Abstract

PURPOSE: To determine the possible biological effects of differently polarised microwave radiation on the chromatin state in human cells. MATERIALS AND METHODS: Isolated human buccal epithelium cells were irradiated by microwaves of frequency f = 35 GHz and surface power density E = 30 microW/cm(2). The state of chromatin in human cells was determined by methods of light and electron microscopy. The state of cell membranes was evaluated by the method of vital indigo carmine staining. RESULTS: The microwave-induced condensation of chromatin in human cells is revealed. Degree of microwave-induced condensation depends on the state of polarisation of electromagnetic wave: In some cases left circularly polarised waves induce less effect than linearly polarised radiation. The linearly polarised electromagnetic waves induce cell membrane damage revealed by increase of cell staining. The data obtained are discussed in connection with mechanisms of biological effects of electromagnetic fields. CONCLUSION: The data obtained in this work demonstrate important biological effects of monochromatic microwave irradiation at 35 GHz. Low-level microwave irradiation induces chromatin condensation in human cells and damages of cell membranes.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeother

Effect directionharm

PopulationIsolated human buccal epithelium cells

Sample sizeNot supplied

ExposuremmWave · 35000 MHz

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Microwave irradiation at 35 GHz (surface power density 30 microW/cm^2) was associated with chromatin condensation in isolated human buccal epithelium cells. The degree of chromatin condensation varied by polarization (left circularly polarized sometimes less than linearly polarized), and linearly polarized waves were associated with increased cell staining interpreted as membrane damage.

Outcomes measured

Chromatin condensation/state (light and electron microscopy)
Cell membrane damage (vital indigo carmine staining)

Limitations

Exposure duration not reported in abstract
Sample size not reported in abstract
Study appears to use isolated human cells (ex vivo); generalizability to in vivo human health outcomes is unclear from abstract
Quantitative effect sizes/statistical analysis not described in abstract

View raw extracted JSON

{
  "study_type": "other",
  "exposure": {
    "band": "mmWave",
    "source": null,
    "frequency_mhz": 35000,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Isolated human buccal epithelium cells",
  "sample_size": null,
  "outcomes": [
    "Chromatin condensation/state (light and electron microscopy)",
    "Cell membrane damage (vital indigo carmine staining)"
  ],
  "main_findings": "Microwave irradiation at 35 GHz (surface power density 30 microW/cm^2) was associated with chromatin condensation in isolated human buccal epithelium cells. The degree of chromatin condensation varied by polarization (left circularly polarized sometimes less than linearly polarized), and linearly polarized waves were associated with increased cell staining interpreted as membrane damage.",
  "effect_direction": "harm",
  "limitations": [
    "Exposure duration not reported in abstract",
    "Sample size not reported in abstract",
    "Study appears to use isolated human cells (ex vivo); generalizability to in vivo human health outcomes is unclear from abstract",
    "Quantitative effect sizes/statistical analysis not described in abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "35 GHz",
    "microwave",
    "millimeter wave",
    "polarization",
    "chromatin condensation",
    "buccal epithelium cells",
    "cell membrane damage",
    "indigo carmine staining",
    "light microscopy",
    "electron microscopy"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1080/09553000902781113
PubMed: 19399677

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