Single strand DNA breaks in rat brain cells exposed to microwave radiation.

Mutation research · 2006 · Harm · Low evidence

← Research stream

HarmLow evidencePaper 6448

Male Wistar rats exposed for 35 days to low-intensity microwave radiation at 2.45 GHz (SAR 1.0 W/kg) or 16.5 GHz (SAR 2.01 W/kg) showed a statistically significant increase (p<0.001) in DNA single strand breaks in brain cells compared with controls, measured …

Study snapshot

PublicationMutation research · 2006

Study typeanimal

Reported directionHarm

Evidence ratingLow

Abstract

This investigation concerns with the effect of low intensity microwave (2.45 and 16.5 GHz, SAR 1.0 and 2.01 W/kg, respectively) radiation on developing rat brain. Wistar rats (35 days old, male, six rats in each group) were selected for this study. These animals were exposed for 35 days at the above mentioned frequencies separately in two different exposure systems. After the exposure period, the rats were sacrificed and the whole brain tissue was dissected and used for study of single strand DNA breaks by micro gel electrophoresis (comet assay). Single strand DNA breaks were measured as tail length of comet. Fifty cells from each slide and two slides per animal were observed. One-way ANOVA method was adopted for statistical analysis. This study shows that the chronic exposure to these radiations cause statistically significant (p<0.001) increase in DNA single strand breaks in brain cells of rat.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionharm

PopulationMale Wistar rats, 35 days old

Sample size12

Exposuremicrowave · 35 days (chronic exposure)

Evidence strengthLowConfidence: 86% · Peer reviewed: yes

Main findings

Outcomes measured

Single strand DNA breaks in brain cells (comet assay tail length)

Limitations

Exposure source and detailed exposure conditions beyond frequency and SAR are not described in the abstract.
Only male rats were studied.
Small group size (six rats per group).
Outcome limited to comet assay tail length in whole brain tissue; no other biological/functional endpoints reported.

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "microwave",
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "35 days (chronic exposure)"
  },
  "population": "Male Wistar rats, 35 days old",
  "sample_size": 12,
  "outcomes": [
    "Single strand DNA breaks in brain cells (comet assay tail length)"
  ],
  "main_findings": "Male Wistar rats exposed for 35 days to low-intensity microwave radiation at 2.45 GHz (SAR 1.0 W/kg) or 16.5 GHz (SAR 2.01 W/kg) showed a statistically significant increase (p<0.001) in DNA single strand breaks in brain cells compared with controls, measured by comet assay tail length.",
  "effect_direction": "harm",
  "limitations": [
    "Exposure source and detailed exposure conditions beyond frequency and SAR are not described in the abstract.",
    "Only male rats were studied.",
    "Small group size (six rats per group).",
    "Outcome limited to comet assay tail length in whole brain tissue; no other biological/functional endpoints reported."
  ],
  "evidence_strength": "low",
  "confidence": 0.86,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "microwave radiation",
    "2.45 GHz",
    "16.5 GHz",
    "SAR",
    "rat brain",
    "DNA damage",
    "single strand breaks",
    "comet assay",
    "chronic exposure"
  ],
  "suggested_hubs": []
}

AI can be wrong. Always verify against the paper.

AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1016/j.mrfmmm.2005.12.006
PubMed: 16458332

Read the original paper →

Related papers

← Back to the Research Library