The effect of electromagnetic field exposure on the formation of DNA single strand breaks in human cells.

Cellular and molecular biology (Noisy-le-Grand, France) · 1994 · No effect · Low evidence

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No effectLow evidencePaper 5452

Using the single cell gel assay, the EMF exposure system used in this study appeared to have no direct effect on DNA single strand break/DNA damage induction across a series of experiments. EMF also did not significantly potentiate DNA damage in cells treated…

Study snapshot

PublicationCellular and molecular biology (Noisy-le-Grand, France) · 1994

Study typein_vitro

Reported directionNo effect

Evidence ratingLow

Abstract

Electromagnetic fields (EMF) have been reported to be associated with human cancers in a number of epidemiological studies. Agents that are associated with cancer affect DNA in an adverse manner. This is a report of a DNA damage study in human cells exposed to EMFs. Single strand breaks in DNA are proposed to be necessary events in both mutagenesis and carcinogenesis. The single cell gel assay is a sensitive and accurate technique that was used in this study for single strand break detection. The EMF exposure system used here appeared to have no direct effect on DNA damage induction in a series of experiments. Moreover, EMF did not have a significant effect in potentiating DNA damage in cells treated with oxidative stresses.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro

Effect directionno_effect

PopulationHuman cells (in vitro)

Sample sizeNot supplied

Exposureunknown

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Outcomes measured

DNA single strand breaks
DNA damage induction
Potentiation of DNA damage under oxidative stress

Limitations

EMF exposure characteristics (e.g., frequency, intensity/SAR, duration) are not specified in the abstract.
Cell type(s) and experimental details are not provided in the abstract.
Sample size and statistical details are not reported in the abstract.

View raw extracted JSON

{
  "study_type": "in_vitro",
  "exposure": {
    "band": "unknown",
    "source": "other",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Human cells (in vitro)",
  "sample_size": null,
  "outcomes": [
    "DNA single strand breaks",
    "DNA damage induction",
    "Potentiation of DNA damage under oxidative stress"
  ],
  "main_findings": "Using the single cell gel assay, the EMF exposure system used in this study appeared to have no direct effect on DNA single strand break/DNA damage induction across a series of experiments. EMF also did not significantly potentiate DNA damage in cells treated with oxidative stresses.",
  "effect_direction": "no_effect",
  "limitations": [
    "EMF exposure characteristics (e.g., frequency, intensity/SAR, duration) are not specified in the abstract.",
    "Cell type(s) and experimental details are not provided in the abstract.",
    "Sample size and statistical details are not reported in the abstract."
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "electromagnetic fields",
    "EMF",
    "DNA damage",
    "single strand breaks",
    "single cell gel assay",
    "comet assay",
    "oxidative stress",
    "human cells",
    "mutagenesis",
    "carcinogenesis"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 8061573

Read the original paper →

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