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Stability of cefazolin sodium admixtures in plastic bags after thawing by microwave radiation.

American journal of hospital pharmacy · 1980 · Unclear · Insufficient evidence

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UnclearInsufficient evidencePaper 6054

After storage at -20°C for 48 hours and thawing to room temperature in a microwave oven, cefazolin sodium admixtures in polyvinyl chloride minibags retained at least 90% of initial antimicrobial activity after an additional four hours at room temperature. Min…

Study snapshot

PublicationAmerican journal of hospital pharmacy · 1980
Study typeother
Reported directionUnclear
Evidence ratingInsufficient

Abstract

The effect on antibiotic stability of thawing, with microwave radiation, cefazolin sodium admixtures frozen in polyvinyl chloride minibags was studied. Two brands of cefazolin sodium (Ancef and Kefzol) were reconstituted and placed in 50-, 100- and 250-ml polyvinyl chloride minibags of 5% dextrose in water or 0.9% sodium chloride. The resulting solutions were assayed for antibiotic stability, using an agar disk diffusion technique, and for pH. The solutions were then stored at -20 degrees C for 48 hours, thawed to room temperature in a microwave oven, and kept at room temperature for four hours, after which they were reassayed for potency and pH. The results indicated that after the freeze-thaw process, the cefazolin sodium minibag admixtures retained at least 90% of their initial antimicrobial activity. The minimal pH changes could not be related to changes in antimicrobial activity, and no color changes could be detected visually. Using a microwave oven can greatly reduce thawing time of antibiotic admixtures. To maintain solution stability and prevent accidents, it is important to calibrate the oven, avoid solution overheating, and observe full precautions in oven operation.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeother
Effect directionunclear
PopulationNot supplied
Sample sizeNot supplied
ExposureNot supplied
Evidence strengthInsufficientConfidence: 66% · Peer reviewed: yes

Main findings

After storage at -20°C for 48 hours and thawing to room temperature in a microwave oven, cefazolin sodium admixtures in polyvinyl chloride minibags retained at least 90% of initial antimicrobial activity after an additional four hours at room temperature. Minimal pH changes were observed and were not related to antimicrobial activity; no visual color changes were detected.

Outcomes measured

  • cefazolin sodium antimicrobial activity/potency after freeze-thaw and microwave thawing
  • pH changes
  • visual color change
View raw extracted JSON
{
  "study_type": "other",
  "exposure": {
    "band": null,
    "source": "microwave oven",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": null,
  "sample_size": null,
  "outcomes": [
    "cefazolin sodium antimicrobial activity/potency after freeze-thaw and microwave thawing",
    "pH changes",
    "visual color change"
  ],
  "main_findings": "After storage at -20°C for 48 hours and thawing to room temperature in a microwave oven, cefazolin sodium admixtures in polyvinyl chloride minibags retained at least 90% of initial antimicrobial activity after an additional four hours at room temperature. Minimal pH changes were observed and were not related to antimicrobial activity; no visual color changes were detected.",
  "effect_direction": "unclear",
  "limitations": [],
  "evidence_strength": "insufficient",
  "confidence": 0.66,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "microwave radiation",
    "microwave oven",
    "cefazolin sodium",
    "Ancef",
    "Kefzol",
    "polyvinyl chloride minibags",
    "freeze-thaw",
    "stability",
    "antibiotic admixtures",
    "agar disk diffusion",
    "pH"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 7361792

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