In vitro effects of microwave radiation on rat liver mitochondria.

Bioelectromagnetics · 1984 · Mixed · Low evidence

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MixedLow evidencePaper 5936

Exposure to 2.45 GHz microwave radiation at 10 or 100 mW/g had no effect on mitochondrial respiration states or respiratory control index with succinate substrate. With glutamate substrate, 100 mW/g exposure increased states 2 and 4 and decreased respiratory …

Study snapshot

PublicationBioelectromagnetics · 1984

Study typein_vitro

Reported directionMixed

Evidence ratingLow

Abstract

Liver mitochondria were exposed in vitro at 30 degrees C to microwave radiation (2.45 GHz) during the following states of respiration: resting, state 1; substrate dependent, state 2; ADP stimulated, state 3; and ADP depleted, state 4. At 10 or 100 mW/g, with succinate as substrate, no effect of exposure was observed on states 1-4 or the respiratory control index (state 3/state 4) of either tightly or loosely coupled mitochondria. When glutamate was used as substrate, no effects were observed at 10 mW/g. However, in the loosely coupled mitochondria the 100 mW/g exposure produced an increase in states 2 and 4 and a decrease in the respiratory control index. The results suggest that the function of loosely coupled mitochondria can be affected at high power levels of microwave radiation.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro

Effect directionmixed

Populationrat liver mitochondria

Sample sizeNot supplied

Exposuremicrowave · 2450 MHz

Evidence strengthLowConfidence: 60% · Peer reviewed: yes

Main findings

Outcomes measured

mitochondrial respiration states 1-4
respiratory control index

Limitations

in vitro study only
no information on exposure duration
limited to rat liver mitochondria
only two power levels tested

View raw extracted JSON

{
  "study_type": "in_vitro",
  "exposure": {
    "band": "microwave",
    "source": null,
    "frequency_mhz": 2450,
    "sar_wkg": null,
    "duration": null
  },
  "population": "rat liver mitochondria",
  "sample_size": null,
  "outcomes": [
    "mitochondrial respiration states 1-4",
    "respiratory control index"
  ],
  "main_findings": "Exposure to 2.45 GHz microwave radiation at 10 or 100 mW/g had no effect on mitochondrial respiration states or respiratory control index with succinate substrate. With glutamate substrate, 100 mW/g exposure increased states 2 and 4 and decreased respiratory control index in loosely coupled mitochondria.",
  "effect_direction": "mixed",
  "limitations": [
    "in vitro study only",
    "no information on exposure duration",
    "limited to rat liver mitochondria",
    "only two power levels tested"
  ],
  "evidence_strength": "low",
  "confidence": 0.6,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "microwave radiation",
    "mitochondria",
    "in vitro",
    "respiration",
    "rat liver"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1002/bem.2250050105
PubMed: 6143563

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