Open-Label Uncontrolled, Monocentric Study to Evaluate the Efficacy and Safety of the Electromagnetic Field and Negative Pressure in the Treatment of Cellulite.

Life (Basel, Switzerland) · 2025 · Benefit · Very low evidence

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BenefitVery low evidencePaper 5889

In 35 women treated weekly for 12 sessions with a vacuum + electromagnetic field device, a statistical difference was recorded in cellulite improvement by VAS and GAIS at 1 month after treatment. The authors conclude the treatment was efficacious and safe.

Study snapshot

PublicationLife (Basel, Switzerland) · 2025

Study typeother

Reported directionBenefit

Evidence ratingVery low

Abstract

UNLABELLED: Cellulite is a widespread aesthetical dermatological condition affecting a significant proportion of postpubertal women, characterized by dimpled skin, primarily on the thighs, buttocks, and hips, which has an important psychological impact. Cellulite, also called lipodystrophy or oedematosclerotic panniculitis, causes an aesthetic change in the skin that affects the epidermis, dermis, hypodermis and subcutaneous fat in different ways. The aim of the present prospective study research was to evaluate the efficacy of electromagnetic field and negative pressure in the treatment of cellulite. METHODS: A total of 35 women with an average age of 40, ranging from 18 to 50 (mean 32.2 ± 7.48), with a body mass index between 18.5 and 26.9 (mean 22 ± 3.01), were enrolled in this study. The degree of cellulite of the patients was assessed clinically using the Cellulite Severity Scale (CSS) and Nürnberger-Müller classification. All patients received one session per week for a total 12 treatment sessions with Bi-one LifeTouchTherapy medical device (Expo Italia Srl-Florence-Italy), which generates a combination of vacuum and electromagnetic fields (V-EMF). Total treatment time was approximately 20-30 min per patient. The GAIS score, Cellulite Severity Scale (CSS) and Nürnberger-Müller classification for cellulite was evaluated 1 month after the 12 treatments with LifeTouchTherapy. RESULTS: A statistical difference was recorded in cellulite improvement by visual analog scale (VAS) and global aesthetic improvement scale (GAIS). CONCLUSIONS: The results of the present prospective clinical study show the efficacy and safety of Bi-one LifeTouchTherapy in the treatment of cellulite. Electromagnetic fields combined with negative pressure therapy promote tissue regeneration and reduce fibrosis, which results in visible cosmetic improvements of cellulite.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeother

Effect directionbenefit

PopulationWomen (postpubertal); cellulite patients

Sample size35

Exposure12 weekly sessions; ~20–30 min per session

Evidence strengthVery lowConfidence: 74% · Peer reviewed: yes

Main findings

Outcomes measured

Cellulite improvement (visual analog scale, VAS)
Global Aesthetic Improvement Scale (GAIS)
Cellulite Severity Scale (CSS)
Nürnberger-Müller cellulite classification
Safety (as stated in conclusions)

Limitations

Open-label design
Uncontrolled study (no comparator group)
Monocentric study
Small sample size (n=35)
Limited follow-up reported (assessment at 1 month after treatments)
Electromagnetic field exposure parameters (e.g., frequency, intensity/SAR) not reported in abstract

View raw extracted JSON

{
  "study_type": "other",
  "exposure": {
    "band": null,
    "source": "medical/aesthetic device (Bi-one LifeTouchTherapy) generating vacuum + electromagnetic fields (V-EMF)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "12 weekly sessions; ~20–30 min per session"
  },
  "population": "Women (postpubertal); cellulite patients",
  "sample_size": 35,
  "outcomes": [
    "Cellulite improvement (visual analog scale, VAS)",
    "Global Aesthetic Improvement Scale (GAIS)",
    "Cellulite Severity Scale (CSS)",
    "Nürnberger-Müller cellulite classification",
    "Safety (as stated in conclusions)"
  ],
  "main_findings": "In 35 women treated weekly for 12 sessions with a vacuum + electromagnetic field device, a statistical difference was recorded in cellulite improvement by VAS and GAIS at 1 month after treatment. The authors conclude the treatment was efficacious and safe.",
  "effect_direction": "benefit",
  "limitations": [
    "Open-label design",
    "Uncontrolled study (no comparator group)",
    "Monocentric study",
    "Small sample size (n=35)",
    "Limited follow-up reported (assessment at 1 month after treatments)",
    "Electromagnetic field exposure parameters (e.g., frequency, intensity/SAR) not reported in abstract"
  ],
  "evidence_strength": "very_low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "cellulite",
    "electromagnetic field",
    "negative pressure",
    "vacuum therapy",
    "aesthetic dermatology",
    "Bi-one LifeTouchTherapy",
    "V-EMF",
    "GAIS",
    "VAS",
    "Cellulite Severity Scale",
    "Nürnberger-Müller classification"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.3390/life15071148
PubMed: 40724650

Read the original paper →

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