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Alternating current electromagnetic field exposure lessens intramyocellular lipid accumulation due to high-fat feeding via enhanced lipid metabolism in mice.

PloS one · 2023 · Benefit · Low evidence

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BenefitLow evidencePaper 5764

In mice on a high-fat diet, alternating current electromagnetic field exposure (max 180 mT; 8 hrs/day for 16 weeks) was associated with lower intramyocellular lipid levels compared with high-fat diet alone. AMPK phosphorylation and FAT/CD-36 and CPT-1b protei…

Study snapshot

PublicationPloS one · 2023
Study typeanimal
Reported directionBenefit
Evidence ratingLow

Abstract

Long-term high-fat feeding results in intramyocellular lipid accumulation, leading to insulin resistance. Intramyocellular lipid accumulation is related to an energy imbalance between excess fat intake and fatty acid consumption. Alternating current electromagnetic field exposure has been shown to enhance mitochondrial metabolism in the liver and sperm. Therefore, we hypothesized that alternating current electromagnetic field exposure would ameliorate high-fat diet-induced intramyocellular lipid accumulation via activation of fatty acid consumption. C57BL/6J mice were either fed a normal diet (ND), a normal diet and exposed to an alternating current electromagnetic field (ND+EMF), a high-fat diet (HFD), or a high-fat diet and exposed to an alternating current electromagnetic field (HFD+EMF). Electromagnetic field exposure was administered 8 hrs/day for 16 weeks using an alternating current electromagnetic field device (max.180 mT, Hokoen, Utatsu, Japan). Tibialis anterior muscles were collected for measurement of intramyocellular lipids, AMPK phosphorylation, FAT/CD-36, and carnitine palmitoyltransferase (CPT)-1b protein expression levels. Intramyocellular lipid levels were lower in the HFD + EMF than in the HFD group. The levels of AMPK phosphorylation, FAT/CD-36, and CPT-1b protein levels were higher in the HFD + EMF than in the HFD group. These results indicate that alternating current electromagnetic field exposure decreases intramyocellular lipid accumulation via increased fat consumption.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionbenefit
PopulationC57BL/6J mice
Sample sizeNot supplied
Exposure8 hrs/day for 16 weeks
Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

In mice on a high-fat diet, alternating current electromagnetic field exposure (max 180 mT; 8 hrs/day for 16 weeks) was associated with lower intramyocellular lipid levels compared with high-fat diet alone. AMPK phosphorylation and FAT/CD-36 and CPT-1b protein levels were higher in the high-fat diet + EMF group than in the high-fat diet group.

Outcomes measured

  • Intramyocellular lipid levels (tibialis anterior muscle)
  • AMPK phosphorylation
  • FAT/CD-36 protein expression
  • Carnitine palmitoyltransferase (CPT)-1b protein expression

Limitations

  • Sample size not reported in the abstract
  • EMF frequency and other exposure parameters beyond maximum magnetic flux density (180 mT) not reported in the abstract
  • Outcomes reported are limited to muscle lipid accumulation and selected molecular markers; insulin resistance outcomes are not described in the abstract
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": null,
    "source": "alternating current electromagnetic field device",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "8 hrs/day for 16 weeks"
  },
  "population": "C57BL/6J mice",
  "sample_size": null,
  "outcomes": [
    "Intramyocellular lipid levels (tibialis anterior muscle)",
    "AMPK phosphorylation",
    "FAT/CD-36 protein expression",
    "Carnitine palmitoyltransferase (CPT)-1b protein expression"
  ],
  "main_findings": "In mice on a high-fat diet, alternating current electromagnetic field exposure (max 180 mT; 8 hrs/day for 16 weeks) was associated with lower intramyocellular lipid levels compared with high-fat diet alone. AMPK phosphorylation and FAT/CD-36 and CPT-1b protein levels were higher in the high-fat diet + EMF group than in the high-fat diet group.",
  "effect_direction": "benefit",
  "limitations": [
    "Sample size not reported in the abstract",
    "EMF frequency and other exposure parameters beyond maximum magnetic flux density (180 mT) not reported in the abstract",
    "Outcomes reported are limited to muscle lipid accumulation and selected molecular markers; insulin resistance outcomes are not described in the abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "alternating current electromagnetic field",
    "high-fat diet",
    "intramyocellular lipid",
    "AMPK phosphorylation",
    "FAT/CD-36",
    "CPT-1b",
    "fatty acid consumption",
    "mouse"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1371/journal.pone.0289086
PubMed: 38011220

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