Treatment with Pulsed Extremely Low Frequency Electromagnetic Field (PELF-EMF) Exhibit Anti-Inflammatory and Neuroprotective Effect in Compression Spinal Cord Injury Model.

Biomedicines · 2022 · Benefit · Low evidence

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BenefitLow evidencePaper 5753

In a compression spinal cord injury mouse model, daily PELF-EMF exposure using the SEQEX device significantly reduced inflammatory cell infiltration and astrocyte activation markers at lesion borders, increased BDNF pro-survival signaling in neuronal cells, a…

Study snapshot

PublicationBiomedicines · 2022

Study typeanimal

Reported directionBenefit

Evidence ratingLow

Abstract

BACKGROUND: Spinal cord injury (SCI) pathology includes both primary and secondary events. The primary injury includes the original traumatic event, and the secondary injury, beginning immediately after the initial injury, involves progressive neuroinflammation, neuronal excitotoxicity, gliosis, and degeneration. Currently, there is no effective neuroprotective treatment for SCI. However, an accumulating body of data suggests that PELF-EMF has beneficial therapeutic effects on neurotrauma. The purpose of this study was to test the efficacy of the PELF-EMF SEQEX device using a compression SCI mouse model. METHODS: C57BL/6 mice were exposed to PELF-EMF for 4 h on a daily basis for two months, beginning 2 h after a mild-moderate compression SCI. RESULTS: The PELF-EMF treatment significantly diminished inflammatory cell infiltration and astrocyte activation by reducing Iba1, F4/80, CD68+ cells, and GAFP at the lesion borders, and increased pro-survival signaling, such as BDNF, on the neuronal cells. Moreover, the treatment exhibited a neuroprotective effect by reducing the demyelination of the axons of the white matter at the lesion's center. CONCLUSIONS: Treatment with SEQEX demonstrated significant anti-inflammatory and neuroprotective effects. Considering our results, this safe and effective rehabilitative device, already available on the market, may provide a major therapeutic asset in the treatment of SCI.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionbenefit

PopulationC57BL/6 mice with mild-moderate compression spinal cord injury model

Sample sizeNot supplied

ExposureELF · 4 h daily for two months; starting 2 h after injury

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Outcomes measured

Inflammatory cell infiltration at lesion borders (Iba1, F4/80, CD68+ cells)
Astrocyte activation at lesion borders (GFAP)
Pro-survival signaling in neuronal cells (BDNF)
Demyelination of white matter axons at lesion center

Limitations

Sample size not reported in abstract
PELF-EMF exposure parameters (e.g., frequency, field strength) not reported in abstract
Animal model; generalizability to humans not established in abstract

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": "therapeutic device (SEQEX)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "4 h daily for two months; starting 2 h after injury"
  },
  "population": "C57BL/6 mice with mild-moderate compression spinal cord injury model",
  "sample_size": null,
  "outcomes": [
    "Inflammatory cell infiltration at lesion borders (Iba1, F4/80, CD68+ cells)",
    "Astrocyte activation at lesion borders (GFAP)",
    "Pro-survival signaling in neuronal cells (BDNF)",
    "Demyelination of white matter axons at lesion center"
  ],
  "main_findings": "In a compression spinal cord injury mouse model, daily PELF-EMF exposure using the SEQEX device significantly reduced inflammatory cell infiltration and astrocyte activation markers at lesion borders, increased BDNF pro-survival signaling in neuronal cells, and reduced demyelination at the lesion center.",
  "effect_direction": "benefit",
  "limitations": [
    "Sample size not reported in abstract",
    "PELF-EMF exposure parameters (e.g., frequency, field strength) not reported in abstract",
    "Animal model; generalizability to humans not established in abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "pulsed extremely low frequency electromagnetic field",
    "PELF-EMF",
    "SEQEX",
    "spinal cord injury",
    "mouse model",
    "neuroinflammation",
    "neuroprotection",
    "BDNF",
    "demyelination",
    "GFAP",
    "Iba1",
    "F4/80",
    "CD68"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.3390/biomedicines10020325
PubMed: 35203533

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