RF Safe

Extremely Low-Frequency Electromagnetic Fields Increase the Expression of Anagen-Related Molecules in Human Dermal Papilla Cells via GSK-3β/ERK/Akt Signaling Pathway.

International journal of molecular sciences · 2020 · Benefit · Low evidence

← Research stream
BenefitLow evidencePaper 5656

hDPCs exposed to 70 Hz ELF-EMFs at intensities from 5 to 100 G for four days showed significantly increased expression of anagen-related molecules (collagen IV, laminin, ALP, versican). An intensity of 10 G was reported as most potent for promoting hDPC proli…

Study snapshot

PublicationInternational journal of molecular sciences · 2020
Study typein_vitro
Reported directionBenefit
Evidence ratingLow

Abstract

Despite advances in medical treatments, the proportion of the population suffering from alopecia is increasing, thereby creating a need for new treatments to control hair loss and prevent balding. Human hair follicle dermal papilla cells (hDPCs), a type of specialized fibroblast in the hair bulb, play an essential role in controlling hair growth and in conditions like androgenic alopecia. This study aimed to evaluate the intensity-dependent effect of extremely low-frequency electromagnetic fields (ELF-EMFs) on the expression of anagen-related molecules in hDPCs in vitro. We examined the effect of ELF-EMF on hDPCs to determine whether activation of the GSK-3β/ERK/Akt signaling pathway improved hDPC activation and proliferation; hDPCs were exposed to ELF-EMFs at a frequency of 70 Hz and at intensities ranging from 5 to 100 G, over four days. Various PEMF intensities significantly increased the expression of anagen-related molecules, including collagen IV, laminin, ALP, and versican. In particular, an intensity of 10 G is most potent for promoting the proliferation of hDPC and expression of anagen-related molecules. Moreover, 10 G ELF-EMF significantly increased β-catenin and Wnt3α expression and GSK-3β/ERK/Akt phosphorylation. Our results confirmed that ELF-EMFs enhance hDPC activation and proliferation via the GSK-3β/ERK/Akt signaling pathway, suggesting a potential treatment strategy for alopecia.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro
Effect directionbenefit
PopulationHuman dermal papilla cells (hDPCs) in vitro
Sample sizeNot supplied
ExposureELF · 4 days
Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

hDPCs exposed to 70 Hz ELF-EMFs at intensities from 5 to 100 G for four days showed significantly increased expression of anagen-related molecules (collagen IV, laminin, ALP, versican). An intensity of 10 G was reported as most potent for promoting hDPC proliferation and increasing β-catenin, Wnt3α, and GSK-3β/ERK/Akt phosphorylation.

Outcomes measured

  • Expression of anagen-related molecules (collagen IV, laminin, ALP, versican)
  • hDPC activation and proliferation
  • β-catenin expression
  • Wnt3α expression
  • GSK-3β/ERK/Akt phosphorylation

Limitations

  • In vitro study in human dermal papilla cells; findings may not translate to clinical outcomes in humans
  • No sample size reported in the abstract
View raw extracted JSON
{
  "study_type": "in_vitro",
  "exposure": {
    "band": "ELF",
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "4 days"
  },
  "population": "Human dermal papilla cells (hDPCs) in vitro",
  "sample_size": null,
  "outcomes": [
    "Expression of anagen-related molecules (collagen IV, laminin, ALP, versican)",
    "hDPC activation and proliferation",
    "β-catenin expression",
    "Wnt3α expression",
    "GSK-3β/ERK/Akt phosphorylation"
  ],
  "main_findings": "hDPCs exposed to 70 Hz ELF-EMFs at intensities from 5 to 100 G for four days showed significantly increased expression of anagen-related molecules (collagen IV, laminin, ALP, versican). An intensity of 10 G was reported as most potent for promoting hDPC proliferation and increasing β-catenin, Wnt3α, and GSK-3β/ERK/Akt phosphorylation.",
  "effect_direction": "benefit",
  "limitations": [
    "In vitro study in human dermal papilla cells; findings may not translate to clinical outcomes in humans",
    "No sample size reported in the abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "extremely low-frequency electromagnetic fields",
    "ELF-EMF",
    "PEMF",
    "70 Hz",
    "gauss",
    "dermal papilla cells",
    "alopecia",
    "hair growth",
    "anagen",
    "β-catenin",
    "Wnt3α",
    "GSK-3β",
    "ERK",
    "Akt"
  ],
  "suggested_hubs": []
}
AI can be wrong. Always verify against the paper.

AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.3390/ijms21030784
PubMed: 31991762

Read the original paper →

Related papers

← Back to the Research Library