Fabrication and physicochemical characterization of a novel magnetic nanocomposite scaffold: Electromagnetic field effect on biological properties.

Materials science & engineering. C, Materials for biological applications · 2020 · Benefit · Low evidence

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BenefitLow evidencePaper 5628

Study snapshot

PublicationMaterials science & engineering. C, Materials for biological applications · 2020

Study typeother

Reported directionBenefit

Evidence ratingLow

Abstract

In the current research, a novel poly(ε-caprolactone) nanofibrous composite scaffold including CZF-NPs (cobalt‑zinc ferrite nanoparticles) was investigated to study the physical, mechanical and biological properties of new magnetic nanofibrous materials and then to evaluate the effect of applied electromagnetic field on biological properties of these scaffolds. It was observed that the incorporation of CZF-NPs up to 3 wt.% leads to decrease in nanofibers' diameter to 466 nm. By raising the content of CZF-NPs, hydrophilicity and biodegradation of magnetic nanofibrous scaffolds improved significantly. In addition, the mechanical properties of nanofibers such as stress at break point was interestingly increased in the sample with 3 wt.% of CZF-NPs. The results of biocompatibility, cell adhesion and cell staining assays with L929 cells are much more improved in nanofibers embedded with CZF-NPs in the presence of external electromagnetic field (EMF). According to this study, magnetic nanofibrous scaffolds composed of PCL/CZF-NPs could be considered as a promising candidate to regenerate damaged tissues.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeother

Effect directionbenefit

PopulationL929 cells

Sample sizeNot supplied

ExposureNot supplied

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Incorporation of cobalt-zinc ferrite nanoparticles (CZF-NPs) into poly(ε-caprolactone) nanofibrous scaffolds altered physicochemical properties (e.g., decreased fiber diameter up to 3 wt.% CZF-NPs; increased hydrophilicity and biodegradation with higher CZF-NP content) and increased stress at break point at 3 wt.% CZF-NPs. Biocompatibility, cell adhesion, and cell staining outcomes in L929 cells were reported as improved for CZF-NP-embedded nanofibers in the presence of an external electromagnetic field.

Outcomes measured

Nanofiber diameter
Hydrophilicity
Biodegradation
Mechanical properties (stress at break point)
Biocompatibility
Cell adhesion
Cell staining assays

Limitations

Electromagnetic field parameters (e.g., frequency, intensity, exposure duration) not reported in the abstract
In vitro cell model only (L929 cells)
Sample size and statistical details not provided in the abstract

View raw extracted JSON

{
  "study_type": "other",
  "exposure": {
    "band": null,
    "source": "external electromagnetic field (EMF)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "L929 cells",
  "sample_size": null,
  "outcomes": [
    "Nanofiber diameter",
    "Hydrophilicity",
    "Biodegradation",
    "Mechanical properties (stress at break point)",
    "Biocompatibility",
    "Cell adhesion",
    "Cell staining assays"
  ],
  "main_findings": "Incorporation of cobalt-zinc ferrite nanoparticles (CZF-NPs) into poly(ε-caprolactone) nanofibrous scaffolds altered physicochemical properties (e.g., decreased fiber diameter up to 3 wt.% CZF-NPs; increased hydrophilicity and biodegradation with higher CZF-NP content) and increased stress at break point at 3 wt.% CZF-NPs. Biocompatibility, cell adhesion, and cell staining outcomes in L929 cells were reported as improved for CZF-NP-embedded nanofibers in the presence of an external electromagnetic field.",
  "effect_direction": "benefit",
  "limitations": [
    "Electromagnetic field parameters (e.g., frequency, intensity, exposure duration) not reported in the abstract",
    "In vitro cell model only (L929 cells)",
    "Sample size and statistical details not provided in the abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "poly(ε-caprolactone)",
    "PCL",
    "nanofibrous scaffold",
    "magnetic nanocomposite",
    "cobalt-zinc ferrite nanoparticles",
    "CZF-NPs",
    "electromagnetic field",
    "EMF",
    "biocompatibility",
    "cell adhesion",
    "L929 cells",
    "tissue regeneration"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1016/j.msec.2020.111222
PubMed: 32806234

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