Low magnetic field effects on embryonic bone growth.

Biomedical sciences instrumentation · 1991 · Unclear · Insufficient evidence

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UnclearInsufficient evidencePaper 5483

Study snapshot

PublicationBiomedical sciences instrumentation · 1991

Study typeanimal

Reported directionUnclear

Evidence ratingInsufficient

Abstract

Pulsed electromagnetic fields [EMF] and electric fields have been demonstrated to promote osteogenesis and wound healing. Pulsed EMF's have been approved since 1979 by the FDA, and are highly effective in the treatment of non-union fractures. Increased linear growth, cellular proliferation, cAMP and uptake of tritiated thymidine have been documented on short term exposure. Yet the mechanisms and the changes that occur have been difficult to quantify. Fluorescence, light, and electron microscopy were utilized in this study to assess any histological changes in bone. During incubation chick embryos were exposed to magnets oriented in various positions. Controls were oriented similarly using galvanized steel plugs. Field density in the center of the field was measure by a gaussmeter with a transverse probe. Each chick embryo in its magnetic field was isolated from the magnetic fields of others by being encased in a steel box. Intramembranous [calvaria] and endochondral [tibia] ossification were studied. Fluorescent dyes were micropipetted intravascularly at various stages of chick development. The tissues were fixed in methacrylate and stained for histomorphological study.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionunclear

Populationchick embryos

Sample sizeNot supplied

Exposureduring incubation (timing not further specified)

Evidence strengthInsufficientConfidence: 62% · Peer reviewed: yes

Main findings

Outcomes measured

embryonic bone growth/ossification
histological changes in bone
intramembranous (calvaria) ossification
endochondral (tibia) ossification

Limitations

No results or quantitative findings are provided in the abstract.
Exposure characteristics are incompletely specified (e.g., field strength values not reported; only that field density was measured).
Sample size and exposure duration details are not stated.

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": null,
    "source": "magnets (static magnetic field exposure during incubation)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "during incubation (timing not further specified)"
  },
  "population": "chick embryos",
  "sample_size": null,
  "outcomes": [
    "embryonic bone growth/ossification",
    "histological changes in bone",
    "intramembranous (calvaria) ossification",
    "endochondral (tibia) ossification"
  ],
  "main_findings": null,
  "effect_direction": "unclear",
  "limitations": [
    "No results or quantitative findings are provided in the abstract.",
    "Exposure characteristics are incompletely specified (e.g., field strength values not reported; only that field density was measured).",
    "Sample size and exposure duration details are not stated."
  ],
  "evidence_strength": "insufficient",
  "confidence": 0.62,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "static magnetic field",
    "magnets",
    "chick embryo",
    "bone growth",
    "osteogenesis",
    "ossification",
    "calvaria",
    "tibia",
    "histology",
    "fluorescence microscopy",
    "electron microscopy"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 2065156

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