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Acute effects of whole-body exposure to static magnetic fields and 50-Hz electromagnetic fields on muscle microcirculation in anesthetized mice.

Bioelectrochemistry (Amsterdam, Netherlands) · 2001 · Benefit · Low evidence

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BenefitLow evidencePaper 5325

Whole-body exposure for 10 min to static magnetic fields (SMF) at 10 mT significantly increased peak blood velocity in tibialis anterior muscle capillaries compared with sham during exposure and post-exposure. After withdrawal of SMF and 50-Hz EMF at 1 mT, si…

Study snapshot

PublicationBioelectrochemistry (Amsterdam, Netherlands) · 2001
Study typeanimal
Reported directionBenefit
Evidence ratingLow

Abstract

Acute microhemodynamic effects of static and alternating magnetic fields at a threshold level were investigated on modulating the muscle capillary mirocirculation in pentobarbital-anesthetized mice. The skin in a tibialis anterior was circularly removed with 1.5 mm diameter for intravital-microscopic recording of the capillary blood velocity in the tibialis anterior muscle. Fluorescein isothiocyanate (FITC)-labeled dextran (MW 150 kDa) was used for an in vivo fluorescent plasma marker of the muscle capillaries. Following a bolus injection of FITC-dextran solution into the caudal vein, the peak blood velocity in the muscle capillaries was measured prior to, during, and following exposure to static magnetic fields (SMF) or 50-Hz electromagnetic fields (EMF) using a fluorescence epi-illumination system. The whole body of experimental animals, placed on the observing stage of a fluorescence microscope, was exposed to SMF (0.3, 1 and 10 mT) or 50-Hz EMF (0.3 and 1 mT) for 10 min using a specially devised electromagnet. For sham exposure, the electromagnet was not energized. During exposure and post-exposure to SMF of 10 mT, the peak blood velocity significantly increased as compared to sham exposure. After the withdrawal of SMF and 50-Hz EMF of 1 mT, significant similar effects on the blood velocity were present or enhanced. These findings suggest that field intensity of 1 mT might be considered as a threshold level for enhancing muscle microcirculation under pentobarbital-induced hypnosis.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionbenefit
PopulationPentobarbital-anesthetized mice
Sample sizeNot supplied
ExposureELF · 10 min
Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Whole-body exposure for 10 min to static magnetic fields (SMF) at 10 mT significantly increased peak blood velocity in tibialis anterior muscle capillaries compared with sham during exposure and post-exposure. After withdrawal of SMF and 50-Hz EMF at 1 mT, significant similar effects on blood velocity were present or enhanced; the authors suggest 1 mT as a threshold level for enhancing muscle microcirculation under pentobarbital-induced hypnosis.

Outcomes measured

  • Muscle capillary peak blood velocity (tibialis anterior microcirculation)

Limitations

  • Sample size not reported in abstract
  • Only acute exposure (10 min) assessed
  • Animal model under pentobarbital anesthesia; generalizability to awake animals or humans unclear
  • Outcome limited to microcirculatory blood velocity in one muscle
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": "laboratory electromagnet (whole-body exposure)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "10 min"
  },
  "population": "Pentobarbital-anesthetized mice",
  "sample_size": null,
  "outcomes": [
    "Muscle capillary peak blood velocity (tibialis anterior microcirculation)"
  ],
  "main_findings": "Whole-body exposure for 10 min to static magnetic fields (SMF) at 10 mT significantly increased peak blood velocity in tibialis anterior muscle capillaries compared with sham during exposure and post-exposure. After withdrawal of SMF and 50-Hz EMF at 1 mT, significant similar effects on blood velocity were present or enhanced; the authors suggest 1 mT as a threshold level for enhancing muscle microcirculation under pentobarbital-induced hypnosis.",
  "effect_direction": "benefit",
  "limitations": [
    "Sample size not reported in abstract",
    "Only acute exposure (10 min) assessed",
    "Animal model under pentobarbital anesthesia; generalizability to awake animals or humans unclear",
    "Outcome limited to microcirculatory blood velocity in one muscle"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "static magnetic field",
    "50-Hz electromagnetic field",
    "ELF",
    "mouse",
    "anesthetized",
    "microcirculation",
    "capillary blood velocity",
    "tibialis anterior",
    "intravital microscopy",
    "FITC-dextran",
    "whole-body exposure",
    "millitesla"
  ],
  "suggested_hubs": [
    {
      "slug": "occupational-exposure",
      "weight": 0.2,
      "reason": "Uses 50-Hz fields at mT levels, relevant to power-frequency exposure contexts, though this is a laboratory animal study."
    }
  ]
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1016/s0302-4598(00)00120-3
PubMed: 11206920

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