RF Safe

The preventive effect on bone loss of 50-Hz, 1-mT electromagnetic field in ovariectomized rats.

Journal of bone and mineral metabolism · 2002 · Benefit · Low evidence

← Research stream
BenefitLow evidencePaper 5290

In ovariectomized rats exposed to a 50 Hz, 1 mT electromagnetic field for 6 weeks, tibia cortical thickness increased (P < 0.002). Tibia Na and K levels increased (P < 0.001 and P < 0.002), and blood ALP increased (P < 0.05), while Ca, Mg, Li, and creatine di…

Study snapshot

PublicationJournal of bone and mineral metabolism · 2002
Study typeanimal
Reported directionBenefit
Evidence ratingLow

Abstract

Osteoporosis is a common health problem, especially in the elderly and in women after menopause. Although there are some treatment methods, they impose serious side effects. Recently, the use of an electromagnetic field (EMF) has been a promising candidate for better treatment of osteoporosis. In the present study, we investigated the preventive effects of low-frequency (50 Hz), low-intensity (1 mT), and long-term (6 weeks) EMF on bone loss in ovariectomized rats. We used 18 female albino Wistar rats (8 unexposed and 10 exposed) to assess the effect of EMF. We examined the mineralization and the morphology of the tibia in control and EMF-exposed rats. The cortical thickness of the tibia was increased in EMF-exposed rats ( P < 0.002). The levels of Na and K in the tibia were significantly increased in rats exposed to EMF ( P < 0.001; P < 0.002, respectively). We also observed an increased blood alkaline phosphatase (ALP) level after EMF exposure ( P < 0.05). No significant differences in the levels of Ca, Mg, Li, or creatine were found between the exposed and unexposed groups. Our data support the notion that an EMF may prove to be an effective treatment method for osteoporosis and other abnormalities related to bone loss.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionbenefit
PopulationOvariectomized female albino Wistar rats
Sample size18
ExposureELF · 6 weeks
Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

In ovariectomized rats exposed to a 50 Hz, 1 mT electromagnetic field for 6 weeks, tibia cortical thickness increased (P < 0.002). Tibia Na and K levels increased (P < 0.001 and P < 0.002), and blood ALP increased (P < 0.05), while Ca, Mg, Li, and creatine did not differ significantly between exposed and unexposed groups.

Outcomes measured

  • Tibia cortical thickness
  • Tibia mineralization
  • Tibia morphology
  • Tibia sodium (Na) level
  • Tibia potassium (K) level
  • Blood alkaline phosphatase (ALP) level
  • Tibia calcium (Ca) level
  • Tibia magnesium (Mg) level
  • Tibia lithium (Li) level
  • Creatine level

Limitations

  • Animal model; findings may not generalize to humans
  • Small sample size (n=18)
  • Exposure source/setup details not described in abstract
  • Randomization/blinding not described in abstract
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "6 weeks"
  },
  "population": "Ovariectomized female albino Wistar rats",
  "sample_size": 18,
  "outcomes": [
    "Tibia cortical thickness",
    "Tibia mineralization",
    "Tibia morphology",
    "Tibia sodium (Na) level",
    "Tibia potassium (K) level",
    "Blood alkaline phosphatase (ALP) level",
    "Tibia calcium (Ca) level",
    "Tibia magnesium (Mg) level",
    "Tibia lithium (Li) level",
    "Creatine level"
  ],
  "main_findings": "In ovariectomized rats exposed to a 50 Hz, 1 mT electromagnetic field for 6 weeks, tibia cortical thickness increased (P < 0.002). Tibia Na and K levels increased (P < 0.001 and P < 0.002), and blood ALP increased (P < 0.05), while Ca, Mg, Li, and creatine did not differ significantly between exposed and unexposed groups.",
  "effect_direction": "benefit",
  "limitations": [
    "Animal model; findings may not generalize to humans",
    "Small sample size (n=18)",
    "Exposure source/setup details not described in abstract",
    "Randomization/blinding not described in abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "extremely low frequency",
    "ELF-EMF",
    "50 Hz",
    "1 mT",
    "ovariectomized rats",
    "bone loss",
    "osteoporosis",
    "tibia",
    "cortical thickness",
    "alkaline phosphatase"
  ],
  "suggested_hubs": []
}
AI can be wrong. Always verify against the paper.

AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1007/s007740200050
PubMed: 12434162

Read the original paper →

Related papers

← Back to the Research Library