The effect of extremely low frequency electromagnetic fields (ELF-EMF) on the frequency of micronuclei and sister chromatid exchange in human lymphocytes induced by benzo(a)pyrene.

Toxicology letters · 2003 · Mixed · Low evidence

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MixedLow evidencePaper 5279

A 60 Hz, 0.8 mT ELF-EMF alone did not significantly change MN or SCE compared with sham-exposed controls. Co-exposure to BP and ELF-EMF for 24 h followed by BP exposure for 48 h significantly increased MN and SCE frequencies compared with BP exposure for 72 h…

Study snapshot

PublicationToxicology letters · 2003

Study typein_vitro

Reported directionMixed

Evidence ratingLow

Abstract

The interaction of extremely low frequency electromagnetic fields (ELF-EMF) on the frequency of micronuclei (MN) and sister chromatid exchange (SCE) induced by benzo(a)pyrene (BP) in human lymphocytes was examined. A 60 Hz ELF-EMF of 0.8 mT field strength was applied either alone or with the tumor initiator, BP for 24 h. The frequencies of MN and SCE induced by BP increased in a dose-dependent manner. The co-exposure of cells to BP and 0.8 mT ELF-EMF for 24 h, followed by BP exposure for 48 h led to significant increases in the frequencies of MN and SCE compared to BP treatment for 72 h alone (P<0.05), but no significant difference was observed between field exposed and sham exposed control cells. The obtained results suggest that low density ELF-EMF could act as an enhancer of the initiation process of BP rather than as an initiator of mutagenic effects in human lymphocytes.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro

Effect directionmixed

PopulationHuman lymphocytes (cells)

Sample sizeNot supplied

ExposureELF · 0.06 MHz · 24 h (ELF-EMF applied alone or with BP); co-exposure 24 h then BP 48 h

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Outcomes measured

Micronuclei (MN) frequency
Sister chromatid exchange (SCE) frequency

Limitations

Sample size not reported in abstract
In vitro study in human lymphocytes; generalizability to in vivo outcomes not established
Exposure conditions limited to 60 Hz at 0.8 mT and specific co-exposure timing with benzo(a)pyrene

View raw extracted JSON

{
  "study_type": "in_vitro",
  "exposure": {
    "band": "ELF",
    "source": null,
    "frequency_mhz": 0.06,
    "sar_wkg": null,
    "duration": "24 h (ELF-EMF applied alone or with BP); co-exposure 24 h then BP 48 h"
  },
  "population": "Human lymphocytes (cells)",
  "sample_size": null,
  "outcomes": [
    "Micronuclei (MN) frequency",
    "Sister chromatid exchange (SCE) frequency"
  ],
  "main_findings": "A 60 Hz, 0.8 mT ELF-EMF alone did not significantly change MN or SCE compared with sham-exposed controls. Co-exposure to BP and ELF-EMF for 24 h followed by BP exposure for 48 h significantly increased MN and SCE frequencies compared with BP exposure for 72 h alone (P<0.05).",
  "effect_direction": "mixed",
  "limitations": [
    "Sample size not reported in abstract",
    "In vitro study in human lymphocytes; generalizability to in vivo outcomes not established",
    "Exposure conditions limited to 60 Hz at 0.8 mT and specific co-exposure timing with benzo(a)pyrene"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "extremely low frequency",
    "ELF-EMF",
    "60 Hz",
    "0.8 mT",
    "human lymphocytes",
    "micronuclei",
    "sister chromatid exchange",
    "benzo(a)pyrene",
    "co-exposure",
    "genotoxicity"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1016/s0378-4274(03)00111-5
PubMed: 12697378

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