[Effect of electromagnetic fields on the chemical composition of regenerative bone under defective ceramic hydroxylapatite plastics].

Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) · 2003 · Benefit · Very low evidence

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BenefitVery low evidencePaper 5265

Study snapshot

PublicationFiziolohichnyi zhurnal (Kiev, Ukraine : 1994) · 2003

Study typeanimal

Reported directionBenefit

Evidence ratingVery low

Abstract

In experiment on white rats with the initial mass 130-150 grams researched influence of volumetric-combinative impulse electromagnetic fields (VCI EMF) with the amplitude of a magnetic field 0.04/0.05 Teslas on composition of a reclaim formative in the field of defect of a tibial bone, filled with ceramic hydroxylapatite (HAP) with a size of particles less than 63 microns. Was researched the exposure by VCI EMF boosts synthesis of organic matters in the field of a forming osteal regenerate in early periods of experiment and accelerates the processes of a mineralization of an organic matrix. was been stated it appears by increase of do the mineral component part in a reclaim. In that case, when the generated osteal defect is filled with ceramic HAP, VCI EMF boosts synthesis of a organic matrix and processes of its mineralization, that leads on to the optimization of chemical composition of a reclaim. In order to use the obtained results in clinical practice, the histological and ultra structural research of a formating reclaim are necessary too. These researches are our proximate task.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionbenefit

PopulationWhite rats (initial mass 130–150 g) with tibial bone defect filled with ceramic hydroxylapatite (HAP) particles <63 microns

Sample sizeNot supplied

ExposureNot supplied

Evidence strengthVery lowConfidence: 66% · Peer reviewed: yes

Main findings

In a rat tibial defect model filled with ceramic hydroxylapatite, exposure to volumetric-combinative impulse electromagnetic fields (VCI EMF) with magnetic field amplitude 0.04/0.05 T was reported to increase synthesis of organic matter in early periods and accelerate mineralization of the organic matrix, reflected by an increased mineral component proportion in the regenerate.

Outcomes measured

Chemical composition of forming bone regenerate (organic matrix synthesis, mineralization, mineral component proportion)

Limitations

Sample size not reported in abstract.
Exposure parameters beyond magnetic field amplitude (e.g., frequency, waveform details, duration) not reported in abstract.
Outcome measures and methods for assessing chemical composition not described in abstract.
Animal model; clinical applicability not established (authors note further histological/ultrastructural studies needed).

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": null,
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "White rats (initial mass 130–150 g) with tibial bone defect filled with ceramic hydroxylapatite (HAP) particles <63 microns",
  "sample_size": null,
  "outcomes": [
    "Chemical composition of forming bone regenerate (organic matrix synthesis, mineralization, mineral component proportion)"
  ],
  "main_findings": "In a rat tibial defect model filled with ceramic hydroxylapatite, exposure to volumetric-combinative impulse electromagnetic fields (VCI EMF) with magnetic field amplitude 0.04/0.05 T was reported to increase synthesis of organic matter in early periods and accelerate mineralization of the organic matrix, reflected by an increased mineral component proportion in the regenerate.",
  "effect_direction": "benefit",
  "limitations": [
    "Sample size not reported in abstract.",
    "Exposure parameters beyond magnetic field amplitude (e.g., frequency, waveform details, duration) not reported in abstract.",
    "Outcome measures and methods for assessing chemical composition not described in abstract.",
    "Animal model; clinical applicability not established (authors note further histological/ultrastructural studies needed)."
  ],
  "evidence_strength": "very_low",
  "confidence": 0.66,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "impulse electromagnetic fields",
    "VCI EMF",
    "magnetic field amplitude",
    "0.04 T",
    "0.05 T",
    "tibial bone defect",
    "bone regeneration",
    "osteal regenerate",
    "mineralization",
    "organic matrix",
    "hydroxylapatite",
    "ceramic HAP",
    "rats"
  ],
  "suggested_hubs": [
    {
      "slug": "animal-studies",
      "weight": 0.9,
      "reason": "Experimental study in white rats assessing EMF effects on bone regenerate composition."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 12945121

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