[Effect of hypokinetic stress and low intensity electromagnetic field of extremely high frequency on changes of cytokine concentration in rat blood].

Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) · 2005 · Mixed · Low evidence

← Research stream

MixedLow evidencePaper 5153

Study snapshot

PublicationFiziolohichnyi zhurnal (Kiev, Ukraine : 1994) · 2005

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

The influence of hypokinetic stress and low-intensive electromagnetic field of extremely high frequency (EMF of EHF) on cytokine concentration changes (IL-1, 2, 4, 6 and TNF-6) in serum of rats was investigated. Using an immunoenzyme method it was shown that the concentration of the investigated cytokines under influence of the hypokinetic stress and low-intensive EMF of EHF is changed in an inversed direction.. An isolated influence of EMF of EHF on animals resulted in significant decrease of IL- 1B concentration and in the tendency of IL-6 concentration reduction while concentration of IL-2, IL-4 and TNF-6 increased. Mobility restriction of animals has caused substantial growth of IL-1B, IL-2, IL-6 and TNF-6 concentration with simultaneous decrease of IL-4 concentration. Variation of the investigated parameters differed considerably from the results obtained for animals in the case of a restricted mobility, which does not take place under activity of EMF of EHF with the combined influence of hypokinesia activity and EMF of EHF. It is assumed that revealed changes of the cytokine profile after the use of low-intensive EMF of EHF resulted in increase of the nonspecific immunological reactivity level of animals that is very important component of its physiological action.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionmixed

PopulationRats

Sample sizeNot supplied

ExposureEHF

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

In rats, isolated low-intensity EHF EMF exposure was associated with a significant decrease in IL-1β and a tendency toward reduced IL-6, while IL-2, IL-4, and TNF-6 increased. Hypokinetic stress (mobility restriction) increased IL-1β, IL-2, IL-6, and TNF-6 and decreased IL-4. The abstract states cytokine changes under hypokinetic stress versus low-intensity EHF EMF occurred in opposite directions, and combined exposure differed from mobility restriction alone.

Outcomes measured

Serum cytokine concentrations: IL-1β, IL-2, IL-4, IL-6, TNF-6

Limitations

Frequency of the EHF field not reported in the abstract
Exposure duration and dosimetry (e.g., SAR) not reported
Sample size not reported
Details of experimental groups and combined-exposure results are not quantitatively described in the abstract
Animal study; relevance to humans not established in the abstract

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "EHF",
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Rats",
  "sample_size": null,
  "outcomes": [
    "Serum cytokine concentrations: IL-1β, IL-2, IL-4, IL-6, TNF-6"
  ],
  "main_findings": "In rats, isolated low-intensity EHF EMF exposure was associated with a significant decrease in IL-1β and a tendency toward reduced IL-6, while IL-2, IL-4, and TNF-6 increased. Hypokinetic stress (mobility restriction) increased IL-1β, IL-2, IL-6, and TNF-6 and decreased IL-4. The abstract states cytokine changes under hypokinetic stress versus low-intensity EHF EMF occurred in opposite directions, and combined exposure differed from mobility restriction alone.",
  "effect_direction": "mixed",
  "limitations": [
    "Frequency of the EHF field not reported in the abstract",
    "Exposure duration and dosimetry (e.g., SAR) not reported",
    "Sample size not reported",
    "Details of experimental groups and combined-exposure results are not quantitatively described in the abstract",
    "Animal study; relevance to humans not established in the abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "extremely high frequency",
    "EHF",
    "low-intensity electromagnetic field",
    "hypokinetic stress",
    "mobility restriction",
    "rats",
    "cytokines",
    "IL-1β",
    "IL-2",
    "IL-4",
    "IL-6",
    "TNF-6",
    "serum",
    "immunoenzyme method"
  ],
  "suggested_hubs": []
}

AI can be wrong. Always verify against the paper.

AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 16485858

Read the original paper →

Related papers

← Back to the Research Library