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[Influence of electromagnetic radiation of different ranges on the transmembrane transport of Na+, K+, and Ca2+ ions in normal and tumor cells].

Georgian medical news · 2006 · Mixed · Low evidence

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MixedLow evidencePaper 5126

In mouse fibroblasts, EMF exposure in the 20–100 Hz range at an inductance of 2.0 mT was associated with stimulation of transmembrane transport of Na+, K+, and Ca2+ at frequencies below 45 Hz and above 60 Hz.

Study snapshot

PublicationGeorgian medical news · 2006
Study typeanimal
Reported directionMixed
Evidence ratingLow

Abstract

The problem of planetary pollution is one of the most pressing ones. In the present work it was determined to assess functional state of a cell according to criterion of transport of Na(+), K(+), and Ca(2+) ions subjected to irradiation with electromagnetic fields (EMF) of different frequency ranges. Recording of the ions' concentration was made with the ion-selective electrodes immersed into the Ringer solution. The ion transport was studied in the fibroblasts of the mice. Influences of the EMF in the range of 20 to 100 Hz and different inductances were assessed. It was found that the frequencies below 45 Hz and above 60 Hz, at inductance of 2,0 mT induced stimulation of transmembrane transport of Na(+), K(+), and Ca(2+) ions. According to some electrophysiologists, this effect must be due to the fact that the frequency below 45 Hz generates potentials too slowly. Therefore an adaptation to this process does occur, while at the higher frequencies velocity of stimulation is so high that the cellular membrane cannot react and, as a result, the effect similar to the first variant is observed.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionmixed
PopulationMouse fibroblasts (normal and tumor cells mentioned in title)
Sample sizeNot supplied
ExposureELF
Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

In mouse fibroblasts, EMF exposure in the 20–100 Hz range at an inductance of 2.0 mT was associated with stimulation of transmembrane transport of Na+, K+, and Ca2+ at frequencies below 45 Hz and above 60 Hz.

Outcomes measured

  • Transmembrane transport of Na+ ions
  • Transmembrane transport of K+ ions
  • Transmembrane transport of Ca2+ ions
  • Ion concentrations in Ringer solution measured with ion-selective electrodes

Limitations

  • No sample size reported in abstract
  • Exposure duration not reported
  • Only fibroblasts are explicitly described in the abstract; details on tumor vs normal cells are not provided in the abstract
  • Outcome is a functional/physiological measure; no health endpoints reported
  • Limited exposure characterization beyond frequency range and inductance
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Mouse fibroblasts (normal and tumor cells mentioned in title)",
  "sample_size": null,
  "outcomes": [
    "Transmembrane transport of Na+ ions",
    "Transmembrane transport of K+ ions",
    "Transmembrane transport of Ca2+ ions",
    "Ion concentrations in Ringer solution measured with ion-selective electrodes"
  ],
  "main_findings": "In mouse fibroblasts, EMF exposure in the 20–100 Hz range at an inductance of 2.0 mT was associated with stimulation of transmembrane transport of Na+, K+, and Ca2+ at frequencies below 45 Hz and above 60 Hz.",
  "effect_direction": "mixed",
  "limitations": [
    "No sample size reported in abstract",
    "Exposure duration not reported",
    "Only fibroblasts are explicitly described in the abstract; details on tumor vs normal cells are not provided in the abstract",
    "Outcome is a functional/physiological measure; no health endpoints reported",
    "Limited exposure characterization beyond frequency range and inductance"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "electromagnetic fields",
    "ELF",
    "20-100 Hz",
    "2.0 mT",
    "inductance",
    "mouse fibroblasts",
    "ion-selective electrodes",
    "Ringer solution",
    "Na+",
    "K+",
    "Ca2+",
    "transmembrane transport"
  ],
  "suggested_hubs": [
    {
      "slug": "occupational-exposure",
      "weight": 0.2,
      "reason": "ELF magnetic field exposure parameters (Hz, mT) may be relevant to occupational/industrial ELF contexts, though no setting is specified."
    }
  ]
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 16783080

Read the original paper →

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