RF Safe

Effects of acute exposure to a 1439 MHz electromagnetic field on the microcirculatory parameters in rat brain.

In vivo (Athens, Greece) · 2007 · No effect · Low evidence

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No effectLow evidencePaper 5052

Rats exposed for 10 minutes to 1439 MHz RF-EMF at brain-averaged SAR doses of 0.6, 2.4, and 4.8 W/kg showed no dye extravasation from pial venules, no significant change in endothelial-adhering leukocytes, and no changes in plasma velocity or vessel diameter …

Study snapshot

PublicationIn vivo (Athens, Greece) · 2007
Study typeanimal
Reported directionNo effect
Evidence ratingLow

Abstract

UNLABELLED: THE AIM of this study was to determine the potential of radio-frequency electromagnetic fields (RF-EMF) to affect cerebral microcirculation, including blood-brain barrier function, in rat brain. MATERIALS AND METHODS: The head of the rat was exposed for 10 min to 1439 MHz RF-EMF having three intensity doses: 0.6, 2.4, 4.8 W/kg of brain averaged specific absorption rate (BASAR). Four microcirculatory parameters: blood-brain barrier permeability, leukocyte behavior, plasma velocity, and vessel diameter were measured before and after RF-EMF exposure using a closed cranial window method. RESULTS: No extravasation of intravenously injected dyes from pial venules was found at any BASAR level. No significant changes in the number of endothelial-adhering leukocytes after exposure were found. The hemodynamics indicated that the plasma velocities and vessel diameters remained constant within the physiological range throughout each exposure. CONCLUSION: These findings suggest that there were no effects on the cerebral microcirculation under the given RF-EMF exposure conditions.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionno_effect
PopulationRats (rat brain)
Sample sizeNot supplied
ExposureRF · 1439 MHz · 4.8 W/kg · 10 min
Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Rats exposed for 10 minutes to 1439 MHz RF-EMF at brain-averaged SAR doses of 0.6, 2.4, and 4.8 W/kg showed no dye extravasation from pial venules, no significant change in endothelial-adhering leukocytes, and no changes in plasma velocity or vessel diameter within physiological range.

Outcomes measured

  • Blood-brain barrier permeability
  • Leukocyte behavior (endothelial-adhering leukocytes)
  • Plasma velocity
  • Vessel diameter

Limitations

  • Sample size not reported in abstract
  • Only acute exposure (10 min) assessed
  • Only selected microcirculatory parameters assessed under the specific exposure conditions
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": null,
    "frequency_mhz": 1439,
    "sar_wkg": 4.8,
    "duration": "10 min"
  },
  "population": "Rats (rat brain)",
  "sample_size": null,
  "outcomes": [
    "Blood-brain barrier permeability",
    "Leukocyte behavior (endothelial-adhering leukocytes)",
    "Plasma velocity",
    "Vessel diameter"
  ],
  "main_findings": "Rats exposed for 10 minutes to 1439 MHz RF-EMF at brain-averaged SAR doses of 0.6, 2.4, and 4.8 W/kg showed no dye extravasation from pial venules, no significant change in endothelial-adhering leukocytes, and no changes in plasma velocity or vessel diameter within physiological range.",
  "effect_direction": "no_effect",
  "limitations": [
    "Sample size not reported in abstract",
    "Only acute exposure (10 min) assessed",
    "Only selected microcirculatory parameters assessed under the specific exposure conditions"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "RF-EMF",
    "1439 MHz",
    "rat",
    "brain",
    "cerebral microcirculation",
    "blood-brain barrier",
    "BASAR",
    "leukocytes",
    "plasma velocity",
    "vessel diameter",
    "closed cranial window"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 17708346

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