RF Safe

Pathological effects of prenatal exposure to a 900 MHz electromagnetic field on the 21-day-old male rat kidney.

Biotechnic & histochemistry : official publication of the Biological Stain Commission · 2015 · Harm · Low evidence

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HarmLow evidencePaper 4666

Male pups prenatally exposed to 900 MHz EMF showed degenerative changes in renal tubule epithelium and cystic formations by light microscopy, and loss of peritubular capillaries with atypical epithelial cells by electron microscopy. Biochemically, the exposed…

Study snapshot

PublicationBiotechnic & histochemistry : official publication of the Biological Stain Commission · 2015
Study typeanimal
Reported directionHarm
Evidence ratingLow

Abstract

We investigated the effects on kidney tissue of 900 megahertz (MHz) EMF applied during the prenatal period. Pregnant rats were exposed to 900 MHz EMF, 1 h/day, on days 13-21 of pregnancy; no procedure was performed on control group pregnant rats or on mothers or newborns after birth. On postnatal day 21, kidney tissues of male rat pups from both groups were examined by light and electron microscopy. Malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and glutathione levels also were investigated. Light microscopy revealed some degenerative changes in the tubule epithelium, small cystic formations in the primitive tubules and large cysts in the cortico-medullary or medullary regions in the experimental group. Electron microscopy revealed a loss of peritubular capillaries and atypical parietal layer epithelial cells in the experimental group. Biochemical analysis showed significantly increased MDA levels in the experimental group and decreased SOD and CAT levels. EMF applied during the prenatal period can caused pathological changes in kidney tissue in 21-day-old male rats owing to oxidative stress and decreased antioxidant enzyme levels.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionharm
PopulationPregnant rats and 21-day-old male rat pups (kidney tissue assessed)
Sample sizeNot supplied
ExposureRF · 900 MHz · 1 h/day on gestational days 13–21
Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Male pups prenatally exposed to 900 MHz EMF showed degenerative changes in renal tubule epithelium and cystic formations by light microscopy, and loss of peritubular capillaries with atypical epithelial cells by electron microscopy. Biochemically, the exposed group had significantly increased MDA and decreased SOD and CAT levels.

Outcomes measured

  • Kidney histopathology (light microscopy)
  • Kidney ultrastructure (electron microscopy)
  • Malondialdehyde (MDA) levels
  • Superoxide dismutase (SOD) levels
  • Catalase (CAT) levels
  • Glutathione levels

Limitations

  • Sample size not reported in the provided abstract/metadata
  • SAR/dosimetry details not reported in the provided abstract/metadata
  • Exposure source/setup not described in the provided abstract/metadata
  • Only male pups assessed at a single postnatal time point (day 21)
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": null,
    "frequency_mhz": 900,
    "sar_wkg": null,
    "duration": "1 h/day on gestational days 13–21"
  },
  "population": "Pregnant rats and 21-day-old male rat pups (kidney tissue assessed)",
  "sample_size": null,
  "outcomes": [
    "Kidney histopathology (light microscopy)",
    "Kidney ultrastructure (electron microscopy)",
    "Malondialdehyde (MDA) levels",
    "Superoxide dismutase (SOD) levels",
    "Catalase (CAT) levels",
    "Glutathione levels"
  ],
  "main_findings": "Male pups prenatally exposed to 900 MHz EMF showed degenerative changes in renal tubule epithelium and cystic formations by light microscopy, and loss of peritubular capillaries with atypical epithelial cells by electron microscopy. Biochemically, the exposed group had significantly increased MDA and decreased SOD and CAT levels.",
  "effect_direction": "harm",
  "limitations": [
    "Sample size not reported in the provided abstract/metadata",
    "SAR/dosimetry details not reported in the provided abstract/metadata",
    "Exposure source/setup not described in the provided abstract/metadata",
    "Only male pups assessed at a single postnatal time point (day 21)"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "prenatal exposure",
    "900 MHz",
    "RF-EMF",
    "rat",
    "kidney",
    "histopathology",
    "electron microscopy",
    "oxidative stress",
    "MDA",
    "SOD",
    "catalase"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.3109/10520295.2014.947322
PubMed: 25158858

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