Comparative and Mixture Effect of Cynodon Dactylon, ElectroMagnetic Field and Insulin on Diabetic Mouse.

Balkan medical journal · 2012 · Mixed · Low evidence

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MixedLow evidencePaper 4487

Study snapshot

PublicationBalkan medical journal · 2012

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

OBJECTIVE: New investigations are in progress to find some alternative treatments for diabetes mellitus. Herbs are some of the interesting medications in this regard. Cynodon dactylon (C.d) is a potential plant to be considered as a new medication. On the other hand, the effect of the Electromagnetic Field (EMF) on bio organisms is becoming clearer. In this study, the effect of C.d, EMF and insulin have been investigated on the diabetic mouse. MATERIAL AND METHODS: Diabetes was induced by a combination of ketamine (60 mg/Kg) and xylazine (10 mg/Kg) which induces a sustained hyperglycemia. Mice were divided into 12 groups: 1) control, 2) normal saline, 3 and 4) 50mg/Kg C.d, 5 and 6) 100 mg/Kg C.d, 7) insulin, 8) insulin and C.d, 9) EMF (110 KHz, 700±20 mG), 10) insulin and EMF, 11) EMF plus C.d and 12) insulin plus C.d and EMF. Blood glucose level was measured after 5 and 60 minutes in C.d administrated groups, and 5 minutes in the other groups by a glucometer set. The data were analyzed by ANOVA and different means were compared by Tukey and Bonferroni tests (p<0.05). RESULTS: According to results, both dosages of C.d had significant lowering effect on blood glucose level. The first dose was more effective than the second, and its impact was just like insulin. The 6(th), 9(th) and 10(th) groups were significant, also. However, they did not show a higher effect than insulin or C.d. The application of EMF had a significant effect compared to the second group, but it did not reduce the glucose level to the normal range. The effect of the 8th group was very impressive and the mean glucose levels in this group were lower than the control group. CONCLUSION: Considering the data, C.d is a good alternative medication for diabetes mellitus.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionmixed

PopulationDiabetic mouse (diabetes induced by ketamine/xylazine)

Sample sizeNot supplied

Exposure0.11 MHz

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

In diabetic mice, EMF exposure (110 kHz, 700±20 mG) produced a statistically significant effect on blood glucose compared with the normal saline group, but did not reduce glucose to the normal range. Cynodon dactylon lowered blood glucose significantly, and combinations including insulin plus Cynodon dactylon showed particularly strong reductions (reported lower than control).

Outcomes measured

Blood glucose level

Limitations

Sample size not reported in abstract.
Exposure duration/timing details for EMF not reported in abstract.
Outcome assessment appears limited to very short timepoints (5 and/or 60 minutes).
Diabetes induction method and grouping described, but randomization/blinding not reported in abstract.
Results are described qualitatively; effect sizes and exact glucose values are not provided in abstract.

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": null,
    "source": "experimental EMF exposure",
    "frequency_mhz": 0.11,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Diabetic mouse (diabetes induced by ketamine/xylazine)",
  "sample_size": null,
  "outcomes": [
    "Blood glucose level"
  ],
  "main_findings": "In diabetic mice, EMF exposure (110 kHz, 700±20 mG) produced a statistically significant effect on blood glucose compared with the normal saline group, but did not reduce glucose to the normal range. Cynodon dactylon lowered blood glucose significantly, and combinations including insulin plus Cynodon dactylon showed particularly strong reductions (reported lower than control).",
  "effect_direction": "mixed",
  "limitations": [
    "Sample size not reported in abstract.",
    "Exposure duration/timing details for EMF not reported in abstract.",
    "Outcome assessment appears limited to very short timepoints (5 and/or 60 minutes).",
    "Diabetes induction method and grouping described, but randomization/blinding not reported in abstract.",
    "Results are described qualitatively; effect sizes and exact glucose values are not provided in abstract."
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "electromagnetic field",
    "EMF",
    "110 kHz",
    "700 mG",
    "Cynodon dactylon",
    "insulin",
    "diabetic mouse",
    "blood glucose",
    "hyperglycemia"
  ],
  "suggested_hubs": [
    {
      "slug": "animal-studies",
      "weight": 0.9,
      "reason": "Experimental study in diabetic mice assessing EMF and other interventions on blood glucose."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.5152/balkanmedj.2012.091
PubMed: 25207031

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