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Synergistic effect of EMF-BEMER-type pulsed weak electromagnetic field and HPMA-bound doxorubicin on mouse EL4 T-cell lymphoma.

Journal of drug targeting · 2011 · Benefit · Low evidence

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BenefitLow evidencePaper 4438

Exposure to low-frequency pulsed EMF produced by a BEMER device slowed tumor mass growth and prolonged survival in mice with EL4 T-cell lymphoma, with a more pronounced effect in nude mice. No measurable serum Hsp70 or increased anti-EL4 antibodies were detec…

Study snapshot

PublicationJournal of drug targeting · 2011
Study typeanimal
Reported directionBenefit
Evidence ratingLow

Abstract

We have investigated the effects of low-frequency pulsed electromagnetic field (LF-EMF) produced by BEMER device on experimental mouse T-cell lymphoma EL4 growing on conventional and/or athymic (nude) mice. Exposure to EMF-BEMER slowed down the growth of tumor mass and prolonged the survival of experimental animals. The effect was more pronounced in immuno-compromised nude mice compared to conventional ones. Acceleration of tumor growth was never observed. No measurable levels of Hsp 70 or increased levels of specific anti-EL4 antibodies were detected in the serum taken from experimental mice before and at different intervals during the experiment, i.e. before solid tumor appeared, at the time of its aggressive growth, and at the terminal stage of the disease. A significant synergizing antitumor effect was seen when EL4 tumor-bearing mice were simultaneously exposed to EMF-BEMER and treated with suboptimal dose of synthetic HPMA copolymer-based doxorubicin, DOX(HYD)-HPMA. Such a combination may be especially useful for heavily treated patients suffering from advanced tumor and requiring additional aggressive chemotherapy which, however, at that time could represent almost life-threatening way of medication.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionbenefit
PopulationMouse model (conventional and athymic/nude mice) with EL4 T-cell lymphoma
Sample sizeNot supplied
ExposureELF
Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Exposure to low-frequency pulsed EMF produced by a BEMER device slowed tumor mass growth and prolonged survival in mice with EL4 T-cell lymphoma, with a more pronounced effect in nude mice. No measurable serum Hsp70 or increased anti-EL4 antibodies were detected. A significant synergistic antitumor effect was reported when EMF exposure was combined with a suboptimal dose of HPMA copolymer-based doxorubicin (DOX(HYD)-HPMA).

Outcomes measured

  • Tumor mass growth
  • Survival
  • Serum Hsp70 levels
  • Specific anti-EL4 antibody levels
  • Antitumor effect in combination with HPMA-bound doxorubicin (DOX(HYD)-HPMA)

Limitations

  • Sample size not reported in abstract
  • Exposure parameters (e.g., frequency, field strength, duration) not specified in abstract
  • Animal model; generalizability to humans not established in abstract
  • Mechanistic markers assessed (Hsp70, antibodies) showed no measurable changes in serum
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": "BEMER device",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Mouse model (conventional and athymic/nude mice) with EL4 T-cell lymphoma",
  "sample_size": null,
  "outcomes": [
    "Tumor mass growth",
    "Survival",
    "Serum Hsp70 levels",
    "Specific anti-EL4 antibody levels",
    "Antitumor effect in combination with HPMA-bound doxorubicin (DOX(HYD)-HPMA)"
  ],
  "main_findings": "Exposure to low-frequency pulsed EMF produced by a BEMER device slowed tumor mass growth and prolonged survival in mice with EL4 T-cell lymphoma, with a more pronounced effect in nude mice. No measurable serum Hsp70 or increased anti-EL4 antibodies were detected. A significant synergistic antitumor effect was reported when EMF exposure was combined with a suboptimal dose of HPMA copolymer-based doxorubicin (DOX(HYD)-HPMA).",
  "effect_direction": "benefit",
  "limitations": [
    "Sample size not reported in abstract",
    "Exposure parameters (e.g., frequency, field strength, duration) not specified in abstract",
    "Animal model; generalizability to humans not established in abstract",
    "Mechanistic markers assessed (Hsp70, antibodies) showed no measurable changes in serum"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "low-frequency pulsed electromagnetic field",
    "LF-EMF",
    "BEMER",
    "mouse",
    "EL4",
    "T-cell lymphoma",
    "tumor growth",
    "survival",
    "HPMA",
    "doxorubicin",
    "synergy"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.3109/1061186x.2011.622403
PubMed: 21981636

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