Effects of short-duration electromagnetic radiation on early postnatal neurogenesis in rats: Fos and NADPH-d histochemical studies.

Acta histochemica · 2011 · Mixed · Low evidence

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MixedLow evidencePaper 4354

Short-duration exposure to 2.45 GHz EMR increased Fos immunoreactivity in the subventricular zone but not in the rostral migratory stream. EMR caused earlier maturation of NADPH-d positive cells in P7 rats and induced immature morphological signs in P28 rats,…

Study snapshot

PublicationActa histochemica · 2011

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

The immediate effects of whole body electromagnetic radiation (EMR) were used to study postnatal neurogenesis in the subventricular zone (SVZ) and rostral migratory stream (RMS) of Wistar rats of both sexes. Newborn postnatal day 7 (P7) and young adult rats (P28) were exposed to pulsed electromagnetic fields (EMF) at a frequency of 2.45 GHz and mean power density of 2.8 mW/cm(2) for 2 h. Post-irradiation changes were studied using immunohistochemical localization of Fos and NADPH-d. We found that short-duration exposure induces increased Fos immunoreactivity selectively in cells of the SVZ of P7 and P28 rats. There were no Fos positive cells visible within the RMS of irradiated rats. These findings indicate that some differences exist in prerequisites of proliferating cells between the SVZ and RMS regardless of the age of the rats. Short-duration exposure also caused praecox maturation of NADPH-d positive cells within the RMS of P7 rats. The NADPH-d positive cells appeared several days earlier than in age-matched controls, and their number and morphology showed characteristics of adult rats. On the other hand, in the young adult P28 rats, EMR induced morphological signs typical of early postnatal age. These findings indicate that EMR causes age-related changes in the production of nitric oxide (NO), which may lead to different courses of the proliferation cascade in newborn and young adult neurogenesis.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionmixed

PopulationWistar rats of both sexes, postnatal day 7 and day 28

Sample sizeNot supplied

Exposuremicrowave · 2450 MHz · 2 hours

Evidence strengthLowConfidence: 40% · Peer reviewed: yes

Main findings

Outcomes measured

Fos immunoreactivity in subventricular zone
NADPH-d positive cell maturation in rostral migratory stream
age-related changes in nitric oxide production affecting neurogenesis

Limitations

No sample size reported
Only two age groups studied
Findings limited to rat model and specific brain regions

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "microwave",
    "source": null,
    "frequency_mhz": 2450,
    "sar_wkg": null,
    "duration": "2 hours"
  },
  "population": "Wistar rats of both sexes, postnatal day 7 and day 28",
  "sample_size": null,
  "outcomes": [
    "Fos immunoreactivity in subventricular zone",
    "NADPH-d positive cell maturation in rostral migratory stream",
    "age-related changes in nitric oxide production affecting neurogenesis"
  ],
  "main_findings": "Short-duration exposure to 2.45 GHz EMR increased Fos immunoreactivity in the subventricular zone but not in the rostral migratory stream. EMR caused earlier maturation of NADPH-d positive cells in P7 rats and induced immature morphological signs in P28 rats, indicating age-related effects on nitric oxide production and neurogenesis.",
  "effect_direction": "mixed",
  "limitations": [
    "No sample size reported",
    "Only two age groups studied",
    "Findings limited to rat model and specific brain regions"
  ],
  "evidence_strength": "low",
  "confidence": 0.4,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "electromagnetic radiation",
    "postnatal neurogenesis",
    "rats",
    "Fos immunoreactivity",
    "NADPH-d",
    "nitric oxide",
    "2.45 GHz",
    "microwave"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1016/j.acthis.2010.09.009
PubMed: 20950843

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