[Effects of low frequency pulsed electric field on insulin studied by fluorescent spectrum].

Guang pu xue yu guang pu fen xi = Guang pu · 2001 · Harm · Very low evidence

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HarmVery low evidencePaper 3866

Experimental results reported that insulin molecular conformation was altered after 30 minutes of pulsed electric field exposure; heat exposure for 50 hours also altered conformation. The authors suggest the conformation change may involve breaking and recomb…

Study snapshot

PublicationGuang pu xue yu guang pu fen xi = Guang pu · 2001

Study typein_vitro

Reported directionHarm

Evidence ratingVery low

Abstract

Insulin, an intercellular signal molecular, plays a critical role in transferring life information. The studies on effects of pulsed electric fields on insulin molecular are meaningful for explaining the mechanism of biological effects of electromagnetic fields. The experiment results demonstrate that the conformation of insulin molecular has been altered by electric fields exposure for 30 minutes or by heat exposure for 50 hours. The results suggest that pulsed electric field exposure as heat exposure will after conformation of insulin molecular by breaking some hydrogen bonds and recombining another hydrogen bonds. The intercellular signal molecular may be an important target of electromagnetic fields.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro

Effect directionharm

PopulationNot supplied

Sample sizeNot supplied

ExposureELF · 30 minutes

Evidence strengthVery lowConfidence: 66% · Peer reviewed: yes

Main findings

Outcomes measured

Insulin molecular conformation (fluorescence spectrum)
Hydrogen bond changes (breaking/recombining; inferred mechanism described)

Limitations

No exposure parameters beyond duration (e.g., field strength, pulse characteristics, frequency) reported in abstract
No sample size or replication details provided in abstract
In vitro molecular outcome; relevance to health outcomes not addressed in abstract

View raw extracted JSON

{
  "study_type": "in_vitro",
  "exposure": {
    "band": "ELF",
    "source": "pulsed electric field",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "30 minutes"
  },
  "population": null,
  "sample_size": null,
  "outcomes": [
    "Insulin molecular conformation (fluorescence spectrum)",
    "Hydrogen bond changes (breaking/recombining; inferred mechanism described)"
  ],
  "main_findings": "Experimental results reported that insulin molecular conformation was altered after 30 minutes of pulsed electric field exposure; heat exposure for 50 hours also altered conformation. The authors suggest the conformation change may involve breaking and recombining hydrogen bonds.",
  "effect_direction": "harm",
  "limitations": [
    "No exposure parameters beyond duration (e.g., field strength, pulse characteristics, frequency) reported in abstract",
    "No sample size or replication details provided in abstract",
    "In vitro molecular outcome; relevance to health outcomes not addressed in abstract"
  ],
  "evidence_strength": "very_low",
  "confidence": 0.66,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "pulsed electric field",
    "low frequency",
    "insulin",
    "fluorescence spectrum",
    "protein conformation",
    "hydrogen bonds",
    "electromagnetic fields"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 12947682

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