Effect of electromagnetic fields and early postoperative 5-fluorouracil on the healing of colonic anastomoses.

International journal of colorectal disease · 2003 · Benefit · Low evidence

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BenefitLow evidencePaper 3847

In rats, EMF stimulation (10.76 mT, 50 Hz) increased hydroxyproline content and anastomotic breaking strength compared with baseline/control values. No differences in hydroxyproline content or breaking strength were found between the 5-FU-only group and contr…

Study snapshot

PublicationInternational journal of colorectal disease · 2003

Study typeanimal

Reported directionBenefit

Evidence ratingLow

Abstract

BACKGROUND AND AIMS: Studies have indicated a deleterious effect of perioperative 5-fluorouracil (5-FU) administration on the healing of intestinal anastomoses. This study examined the effect of early postoperative 5-FU on the healing of colonic anastomoses and investigated the effect of electromagnetic fields (EMF) on colonic anastomotic repair under normal physiological conditions and in the presence of 5-FU therapy in a rat model. MATERIALS AND METHODS: Forty male Wistar rats were randomly assigned into four groups and underwent a standardized left colonic resection and anastomoses. The animals then served as control or received intraperitoneal 5-FU (20 mg/kg per day, 5 days), EMF stimulation (10.76 mT, 50 Hz; 2-h on/10-h off cycles, 7 days) or both, starting on the day of surgery. After 7 days anastomotic healing was assessed by measurement of hydroxyproline content and breaking strength. RESULTS: Hydroxyproline content increased in EMF exposed group (1.53+/-0.11 to 1.92+/-0.11 microg/mg) and in EMF + 5-FU group (1.53+/-0.11 to 1.89+/-0.12 microg/mg). Breaking strength also increased in the EMF group (0.23+/-0.02 to 0.27+/-0.01 MPa) and in the EMF + 5-FU group (0.23+/-0.02 to 0.28+/-0.01 MPa. No differences were found in hydroxyproline content or breaking strength between the 5-FU group and controls. CONCLUSION: Early postoperative 5-FU administration did not impair the healing of colonic anastomoses in rats. Additionally, EMF stimulation provided a significant gain in colonic anastomotic strength, in rat intestines in control animals and in animals exposed to 5-FU.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionbenefit

PopulationMale Wistar rats with standardized left colonic resection and anastomosis

Sample size40

ExposureELF · 2-h on/10-h off cycles for 7 days (starting day of surgery)

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Outcomes measured

Anastomotic healing (hydroxyproline content)
Anastomotic breaking strength

Limitations

Animal (rat) model; may not generalize to humans
Short follow-up (7 days)
Exposure source/device not described beyond field strength and frequency
Outcomes limited to hydroxyproline content and breaking strength

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": "other",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "2-h on/10-h off cycles for 7 days (starting day of surgery)"
  },
  "population": "Male Wistar rats with standardized left colonic resection and anastomosis",
  "sample_size": 40,
  "outcomes": [
    "Anastomotic healing (hydroxyproline content)",
    "Anastomotic breaking strength"
  ],
  "main_findings": "In rats, EMF stimulation (10.76 mT, 50 Hz) increased hydroxyproline content and anastomotic breaking strength compared with baseline/control values. No differences in hydroxyproline content or breaking strength were found between the 5-FU-only group and controls. EMF plus 5-FU also showed increased hydroxyproline and breaking strength.",
  "effect_direction": "benefit",
  "limitations": [
    "Animal (rat) model; may not generalize to humans",
    "Short follow-up (7 days)",
    "Exposure source/device not described beyond field strength and frequency",
    "Outcomes limited to hydroxyproline content and breaking strength"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "electromagnetic fields",
    "ELF",
    "50 Hz",
    "10.76 mT",
    "colonic anastomosis",
    "wound healing",
    "hydroxyproline",
    "breaking strength",
    "5-fluorouracil",
    "rat model"
  ],
  "suggested_hubs": [
    {
      "slug": "elF-emf",
      "weight": 0.8,
      "reason": "Exposure is 50 Hz, 10.76 mT electromagnetic field stimulation in an animal model."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1007/s00384-002-0454-z
PubMed: 12548416

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