Effect of combined treatment with paroxetine and transcranial magnetic stimulation (TMS) on the mitogen-induced proliferative response of rat lymphocytes.

Polish journal of pharmacology · 2002 · Mixed · Low evidence

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MixedLow evidencePaper 3816

In rats treated for 12 days, paroxetine alone (10 mg/kg) or TMS alone (B=1.2 T, 30 Hz, 330 s) had no effect on mitogen-induced lymphocyte proliferative responses. Combined paroxetine + TMS significantly depressed the proliferative response.

Study snapshot

PublicationPolish journal of pharmacology · 2002

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

Depression is associated with abnormal functions of the immune system. In this study, we investigated how two modem antidepressant therapies, chronic treatment with transcranial magnetic stimulation (TMS) and administration of an antidepressant belonging to selective serotonin reuptake inhibitors (SSRI), paroxetine, affect the proliferative response of thymocytes and splenocytes stimulated in vitro with various mitogens. Paroxetine (10 mg/kg) and TMS (B = 1.2 T, f = 30 Hz, t = 330 s) were applied once daily for 12 consecutive days, while, if given jointly paroxetine was injected 30 min before TMS. The mitogens used were: concanavalin A (Con A), pokeweed mitogen (PWM) or lipopolysaccharide (LPS). While either treatment applied alone had no effect on proliferative response, the joint application of paroxetine and TMS significantly depressed it. The literature data suggest that pulsed magnetic field may directly inhibit mitogen-activated lymphocyte proliferation, which is also inhibited by the presence of high level of serotonin. The present results suggest that both effects are additive, and because of that application of both treatments, whose effects alone are insufficient to prompt the reaction, possibly because adaptive changes during chronic treatment, results in a significant inhibition of lymphocyte proliferation.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionmixed

PopulationRat lymphocytes (thymocytes and splenocytes)

Sample sizeNot supplied

Exposure330 s once daily for 12 consecutive days

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Outcomes measured

Mitogen-induced proliferative response of thymocytes and splenocytes in vitro (Con A, PWM, LPS stimulation)

Limitations

Sample size not reported in abstract
Outcome measured in vitro after in vivo treatments; clinical relevance not established in abstract
Only one TMS exposure setting and one paroxetine dose described in abstract

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": null,
    "source": "transcranial magnetic stimulation (TMS)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "330 s once daily for 12 consecutive days"
  },
  "population": "Rat lymphocytes (thymocytes and splenocytes)",
  "sample_size": null,
  "outcomes": [
    "Mitogen-induced proliferative response of thymocytes and splenocytes in vitro (Con A, PWM, LPS stimulation)"
  ],
  "main_findings": "In rats treated for 12 days, paroxetine alone (10 mg/kg) or TMS alone (B=1.2 T, 30 Hz, 330 s) had no effect on mitogen-induced lymphocyte proliferative responses. Combined paroxetine + TMS significantly depressed the proliferative response.",
  "effect_direction": "mixed",
  "limitations": [
    "Sample size not reported in abstract",
    "Outcome measured in vitro after in vivo treatments; clinical relevance not established in abstract",
    "Only one TMS exposure setting and one paroxetine dose described in abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "transcranial magnetic stimulation",
    "TMS",
    "pulsed magnetic field",
    "paroxetine",
    "SSRI",
    "rat",
    "thymocytes",
    "splenocytes",
    "lymphocyte proliferation",
    "immune function",
    "mitogens",
    "Con A",
    "pokeweed mitogen",
    "lipopolysaccharide"
  ],
  "suggested_hubs": [
    {
      "slug": "tms",
      "weight": 0.86,
      "reason": "Study evaluates biological effects of transcranial magnetic stimulation exposure."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 12866718

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