[Electromagnetic noise blocks the gap-junctional intercellular communication suppression induced by 50 Hz magnetic field].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases · 2002 · Mixed · Low evidence

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MixedLow evidencePaper 3808

Study snapshot

PublicationZhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases · 2002

Study typein_vitro

Reported directionMixed

Evidence ratingLow

Abstract

OBJECTIVE: To explore whether the superposition of an electromagnetic noise can block gap-junctional intercellular communication(GJIC) suppression induced by 50 Hz 0.4 mT extremely low frequency magnetic field(ELF MF). METHODS: Fibroblast cells of mice(NIH 3T3) were exposed to 0.4 mT ELF MF or(and) electromagnetic noise with the same intensity of MF for 24 h, and the GJIC was determined by using fluorescence recovery after photobleaching(FRAP) analysis, which was performed with a laser-scanning confocal microscope(Leica, Germany). RESULTS: ELF MF exposure significantly inhibited GJIC with fluorescence recovery rate of 27.67% +/- 5.12% as compared with the control group(45.57% +/- 9.72%) (P < 0.01), while that of ELF MF plus noise group was (52.61% +/- 8.30%), which was significantly different from ELF MF group(P < 0.01), but not from control(P > 0.05). CONCLUSION: Electromagnetic noise could block the GJIC suppression induced by 50 Hz 0.4 mT MF.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro

Effect directionmixed

PopulationMouse fibroblast cells (NIH 3T3)

Sample sizeNot supplied

ExposureELF · 0.05 MHz · 24 h

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Exposure to a 50 Hz, 0.4 mT extremely low frequency magnetic field for 24 h significantly inhibited GJIC compared with control (fluorescence recovery rate 27.67% ± 5.12% vs 45.57% ± 9.72%; P<0.01). Co-exposure to electromagnetic noise of the same magnetic field intensity resulted in a fluorescence recovery rate of 52.61% ± 8.30%, significantly different from ELF MF alone (P<0.01) but not different from control (P>0.05).

Outcomes measured

Gap-junctional intercellular communication (GJIC) assessed by fluorescence recovery after photobleaching (FRAP)
Fluorescence recovery rate (%)

Limitations

In vitro cell model; findings may not generalize to humans
Sample size not reported in abstract
Exposure characterization of the electromagnetic noise (e.g., frequency content) not described in abstract

View raw extracted JSON

{
  "study_type": "in_vitro",
  "exposure": {
    "band": "ELF",
    "source": "other",
    "frequency_mhz": 0.05,
    "sar_wkg": null,
    "duration": "24 h"
  },
  "population": "Mouse fibroblast cells (NIH 3T3)",
  "sample_size": null,
  "outcomes": [
    "Gap-junctional intercellular communication (GJIC) assessed by fluorescence recovery after photobleaching (FRAP)",
    "Fluorescence recovery rate (%)"
  ],
  "main_findings": "Exposure to a 50 Hz, 0.4 mT extremely low frequency magnetic field for 24 h significantly inhibited GJIC compared with control (fluorescence recovery rate 27.67% ± 5.12% vs 45.57% ± 9.72%; P<0.01). Co-exposure to electromagnetic noise of the same magnetic field intensity resulted in a fluorescence recovery rate of 52.61% ± 8.30%, significantly different from ELF MF alone (P<0.01) but not different from control (P>0.05).",
  "effect_direction": "mixed",
  "limitations": [
    "In vitro cell model; findings may not generalize to humans",
    "Sample size not reported in abstract",
    "Exposure characterization of the electromagnetic noise (e.g., frequency content) not described in abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "extremely low frequency",
    "50 Hz",
    "0.4 mT",
    "magnetic field",
    "electromagnetic noise",
    "NIH 3T3",
    "fibroblast",
    "gap junction",
    "GJIC",
    "FRAP"
  ],
  "suggested_hubs": [
    {
      "slug": "mechanisms-in-vitro",
      "weight": 0.86,
      "reason": "Cell-culture experiment assessing GJIC changes under ELF magnetic field exposure and modulation by electromagnetic noise."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 14694643

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