Experimental studies on ultralow frequency pulsed gradient magnetic field inducing apoptosis of cancer cell and inhibiting growth of cancer cell.

Science in China. Series C, Life sciences · 2002 · Benefit · Low evidence

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BenefitLow evidencePaper 3762

Study snapshot

PublicationScience in China. Series C, Life sciences · 2002

Study typeanimal

Reported directionBenefit

Evidence ratingLow

Abstract

The morphology characteristics of cell apoptosis of the malignant tumour cells in magnetic field-treated mouse was observed for the first time. The apoptotic cancer cell contracted, became rounder and divorced from adjacent cells; the heterochromatin condensed and coagulated together along the inner side of the nuclear membrane; the endoplasmic reticulums (ER) expanded and fused with the cellular membrane; many apoptotic bodies which were packed by the cellular membrane appeared and were devoured by some lymphocytes and plasma. Apoptosis of cancer cells was detected by terminal deoxynucleotidyl transferase mediatedin situ nick end labeling (TUNEL). It was found that the number of apoptosis cancer cells of the sample treated by the magnetic field is more than that of the control sample. The growth of malignant tumour in mice was inhibited and the ability of immune cell to dissolve cancer cells was improved by ultralow frequency (ULF) pulsed gradient magnetic field; the nuclei DNA contents decreased, indicating that magnetic field can block DNA replication and inhibit mitosis of cancer cells. It was suggested that magnetic field could inhibit the metabolism of cancer cell, lower its malignancy, and restrain its rapid and heteromorphic growth. Since ULF pulsed gradient magnetic field can induce apoptosis of cancer cells and inhibit the growth of malignant tumour, it could be used as a new method to treat cancer.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionbenefit

PopulationMice with malignant tumour (mouse tumour model)

Sample sizeNot supplied

ExposureULF

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

In a mouse malignant tumour model, ultralow frequency (ULF) pulsed gradient magnetic field treatment was associated with more apoptotic cancer cells than in controls (including TUNEL detection) and inhibited tumour growth. The abstract also reports improved immune cell ability to dissolve cancer cells and decreased nuclear DNA content, interpreted as blocking DNA replication and inhibiting mitosis.

Outcomes measured

Cancer cell apoptosis (morphology)
TUNEL-detected apoptosis
Tumour growth inhibition
Immune cell ability to dissolve cancer cells
Nuclear DNA content / DNA replication and mitosis

Limitations

No exposure parameters reported (e.g., field strength, pulse characteristics, frequency).
Sample size not reported.
No details on study design (randomization/blinding) or statistical methods in abstract.
Outcomes and measurements are described qualitatively; magnitude of effects not provided.

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "ULF",
    "source": "other",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Mice with malignant tumour (mouse tumour model)",
  "sample_size": null,
  "outcomes": [
    "Cancer cell apoptosis (morphology)",
    "TUNEL-detected apoptosis",
    "Tumour growth inhibition",
    "Immune cell ability to dissolve cancer cells",
    "Nuclear DNA content / DNA replication and mitosis"
  ],
  "main_findings": "In a mouse malignant tumour model, ultralow frequency (ULF) pulsed gradient magnetic field treatment was associated with more apoptotic cancer cells than in controls (including TUNEL detection) and inhibited tumour growth. The abstract also reports improved immune cell ability to dissolve cancer cells and decreased nuclear DNA content, interpreted as blocking DNA replication and inhibiting mitosis.",
  "effect_direction": "benefit",
  "limitations": [
    "No exposure parameters reported (e.g., field strength, pulse characteristics, frequency).",
    "Sample size not reported.",
    "No details on study design (randomization/blinding) or statistical methods in abstract.",
    "Outcomes and measurements are described qualitatively; magnitude of effects not provided."
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "ultralow frequency",
    "ULF",
    "pulsed gradient magnetic field",
    "magnetic field",
    "apoptosis",
    "TUNEL",
    "malignant tumour",
    "mouse",
    "tumour growth",
    "DNA replication",
    "mitosis",
    "immune cells"
  ],
  "suggested_hubs": [
    {
      "slug": "animal-studies",
      "weight": 0.78,
      "reason": "Mouse tumour model assessing biological effects of magnetic-field exposure."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1360/02yc9004
PubMed: 18763061

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