Effects of long-term 50 Hz magnetic field exposure on the micro nucleated polychromatic erythrocyte and blood lymphocyte frequency and argyrophilic nucleolar organizer regions in lymphocytes of mice.

Neuro endocrinology letters · 2010 · No effect · Low evidence

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No effectLow evidencePaper 4382

Exposure to 50 Hz ELF-EMFs up to 5 microT caused nonlinear changes in nucleus size and AgNOR areas but did not significantly affect the frequency of MPBLs or MPCEs. Micronucleus number per PBL was significantly higher in 4 and 5 microT groups, but overall the…

Study snapshot

PublicationNeuro endocrinology letters · 2010

Study typeanimal

Reported directionNo effect

Evidence ratingLow

Abstract

OBJECTIVES: We aimed to investigate the effects of weak extremely low frequency electromagnetic fields (ELF-EMFs) on the nucleus size, the silver staining nucleolar organizer regions (AgNORs), the frequency of micro nucleated peripheral blood lymphocytes (MPBLs) and the micro nucleated polychromatic erythrocytes (MPCEs). METHODS: One hundred and twenty Swiss albino mice were equally divided into 6 groups. The study groups were exposed to 1, 2, 3, 4 and 5 microT 50 Hz-EMFs for 40 days. Micronucleus number (MN) per PBL was determined.. RESULTS: ELF-EMF exposure caused a nonlinear decline of nucleus area. A sharp drop occurred in AgNOR area of 1 microT group, and following it gained an insignificantly higher level than that of the control group. The field did not change mean AgNOR numbers per nucleus of the groups. Relative AgNOR area had the highest level in 1 microT-exposure group, and the level was quite similar to that of the 5 microT-exposure group. The remaining groups had significantly lower values quite similar to that of the control level. The field exposure at any intensity did not affect significantly the frequency of either MPBLs or MPCEs. The number of MN per PBL in the 4 and 5 microT-exposure groups were significantly higher than those of the lower intensity exposure groups. The males in 4 microT-exposure group displayed the highest MN number per PBL, whereas values changed in a nonlinear manner. CONCLUSIONS: The results of the present study suggest that </=5 microT intensities of 50 Hz EMFs did not cause genotoxic effect on the mouse.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionno_effect

PopulationSwiss albino mice

Sample size120

ExposureELF · 0.05 MHz · 40 days

Evidence strengthLowConfidence: 40% · Peer reviewed: yes

Main findings

Outcomes measured

nucleus size
silver staining nucleolar organizer regions (AgNORs)
frequency of micro nucleated peripheral blood lymphocytes (MPBLs)
frequency of micro nucleated polychromatic erythrocytes (MPCEs)
micronucleus number per peripheral blood lymphocyte (MN per PBL)

Limitations

Study limited to mice and specific exposure intensities up to 5 microT
Nonlinear and variable responses complicate interpretation
No direct measurement of SAR or detailed dosimetry provided

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": null,
    "frequency_mhz": 0.05,
    "sar_wkg": null,
    "duration": "40 days"
  },
  "population": "Swiss albino mice",
  "sample_size": 120,
  "outcomes": [
    "nucleus size",
    "silver staining nucleolar organizer regions (AgNORs)",
    "frequency of micro nucleated peripheral blood lymphocytes (MPBLs)",
    "frequency of micro nucleated polychromatic erythrocytes (MPCEs)",
    "micronucleus number per peripheral blood lymphocyte (MN per PBL)"
  ],
  "main_findings": "Exposure to 50 Hz ELF-EMFs up to 5 microT caused nonlinear changes in nucleus size and AgNOR areas but did not significantly affect the frequency of MPBLs or MPCEs. Micronucleus number per PBL was significantly higher in 4 and 5 microT groups, but overall the study suggests no genotoxic effect at or below 5 microT.",
  "effect_direction": "no_effect",
  "limitations": [
    "Study limited to mice and specific exposure intensities up to 5 microT",
    "Nonlinear and variable responses complicate interpretation",
    "No direct measurement of SAR or detailed dosimetry provided"
  ],
  "evidence_strength": "low",
  "confidence": 0.4,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "ELF-EMF",
    "50 Hz",
    "magnetic field",
    "micronucleus",
    "polychromatic erythrocytes",
    "lymphocytes",
    "genotoxicity",
    "mouse"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 20424591

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