Analysis of Transmembrane Potentials Induced by Pulsed Electric Field with Different Durations Based on Five-shelled Dielectric Model of Cell.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference · 2005 · Unclear · Insufficient evidence

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UnclearInsufficient evidencePaper 3596

Study snapshot

PublicationConference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference · 2005

Study typeengineering

Reported directionUnclear

Evidence ratingInsufficient

Abstract

In order to account for the influence of subcellular organelles on transmembrane potential, five-shelled dielectric model of spherical cell was developed in this paper. And the calculation method of transmembrane potential induced by any pulsed electric field (PEF) was put forward. Thus the effects of different pulse duration on transmembrane potentials of cell membrane and nuclear membrane were also analyzed. It is shown that there is a strong relationship between the amplitude and waveform of transmembrane potential and pulse duration. PEF with shorter duration can reaches into the cell easily, thus with shorter duration pulses, transmembrane potential of nuclear membrane is increasing and close to that of cell membrane. So PEF with shorter duration will bring on some important biological effects, such as electroporation or apoptosis.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeengineering

Effect directionunclear

PopulationNot supplied

Sample sizeNot supplied

Exposuredifferent pulse durations (shorter vs longer)

Evidence strengthInsufficientConfidence: 74% · Peer reviewed: yes

Main findings

A five-shelled dielectric spherical cell model was developed to account for subcellular organelles and used to calculate transmembrane potentials induced by pulsed electric fields. The model analysis indicates a strong relationship between pulse duration and the amplitude/waveform of transmembrane potentials; shorter-duration pulses more readily reach into the cell, increasing nuclear membrane transmembrane potential and making it closer to that of the cell membrane.

Outcomes measured

Transmembrane potential (cell membrane)
Transmembrane potential (nuclear membrane)
Relationship of transmembrane potential amplitude/waveform with pulse duration

Limitations

Modeling/analytical study; no experimental or epidemiological data described in the abstract
No quantitative exposure parameters (field strength, pulse duration values) reported in the abstract
Biological effects (e.g., electroporation/apoptosis) are suggested rather than demonstrated in the abstract

View raw extracted JSON

{
  "study_type": "engineering",
  "exposure": {
    "band": null,
    "source": "pulsed electric field (PEF)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "different pulse durations (shorter vs longer)"
  },
  "population": null,
  "sample_size": null,
  "outcomes": [
    "Transmembrane potential (cell membrane)",
    "Transmembrane potential (nuclear membrane)",
    "Relationship of transmembrane potential amplitude/waveform with pulse duration"
  ],
  "main_findings": "A five-shelled dielectric spherical cell model was developed to account for subcellular organelles and used to calculate transmembrane potentials induced by pulsed electric fields. The model analysis indicates a strong relationship between pulse duration and the amplitude/waveform of transmembrane potentials; shorter-duration pulses more readily reach into the cell, increasing nuclear membrane transmembrane potential and making it closer to that of the cell membrane.",
  "effect_direction": "unclear",
  "limitations": [
    "Modeling/analytical study; no experimental or epidemiological data described in the abstract",
    "No quantitative exposure parameters (field strength, pulse duration values) reported in the abstract",
    "Biological effects (e.g., electroporation/apoptosis) are suggested rather than demonstrated in the abstract"
  ],
  "evidence_strength": "insufficient",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "pulsed electric field",
    "transmembrane potential",
    "five-shelled dielectric model",
    "cell membrane",
    "nuclear membrane",
    "pulse duration",
    "electroporation",
    "apoptosis"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1109/iembs.2005.1615401
PubMed: 17281171

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