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Efficacy of static magnetic field for locomotor activity of experimental osteopenia.

Evidence-based complementary and alternative medicine : eCAM · 2007 · Benefit · Low evidence

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BenefitLow evidencePaper 3505

In ovariectomized rats, 12-week exposure to a static magnetic field inhibited the reduction in bone mineral density observed in OVX controls without SMF. After SMF exposure, OVX rats showed a more regular, diphasic locomotor activity pattern with clear active…

Study snapshot

PublicationEvidence-based complementary and alternative medicine : eCAM · 2007
Study typeanimal
Reported directionBenefit
Evidence ratingLow

Abstract

In order to examine the effectiveness of applying a static magnetic field (SMF) for increasing bone mineral density (BMD), we assessed the degree of osteopenia by dual-energy X-ray absorptiometry (DEXA), the metabolism measuring system, and histological examination of bone tissue in an ovariectomized (OVX) rat model. Thirty-six female Wistar rats (8 weeks old, 160-180 g) were divided into three groups. The rats in the OVX-M group were exposed to SMF for 12 weeks after ovariectomy. The ovariectomized rats in the OVX-D group were not exposed to SMF as a control. The rats in the normal group received neither ovariectomy nor exposure to SMF. Twelve-week exposure to SMF in the OVX-M group inhibited the reduction in BMD that was observed in the OVX-D group. Moreover, in the OVX rats, before exposure to SMF, there was no clear difference in the level of locomotor activity between the active and resting phases, and the pattern of locomotor activity was irregular. After exposure of OVX rats to SMF, the pattern of locomotor activity became diphasic with clear active and resting phases, as was observed in the normal group. In the OVX-M group, the continuity of the trabecular bone was maintained more favorably and bone mass was higher than the respective parameters in the OVX-D group. These results demonstrate that exposure to SMF increased the level of locomotor activity in OVX rats, thereby increasing BMD.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionbenefit
PopulationOvariectomized (OVX) female Wistar rats (8 weeks old, 160–180 g)
Sample size36
Exposurestatic · 12 weeks
Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

In ovariectomized rats, 12-week exposure to a static magnetic field inhibited the reduction in bone mineral density observed in OVX controls without SMF. After SMF exposure, OVX rats showed a more regular, diphasic locomotor activity pattern with clear active/resting phases, and histology indicated more favorable maintenance of trabecular bone continuity and higher bone mass versus OVX controls.

Outcomes measured

  • Bone mineral density (BMD) by DEXA
  • Locomotor activity pattern (metabolism measuring system)
  • Histological examination of bone tissue (trabecular bone continuity, bone mass)

Limitations

  • Magnetic field strength and exposure parameters (beyond duration) not reported in the abstract
  • Animal model (OVX rats); generalizability to humans not established in the abstract
  • No details provided on randomization/blinding or statistical methods in the abstract
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "static",
    "source": "static magnetic field (SMF) exposure",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "12 weeks"
  },
  "population": "Ovariectomized (OVX) female Wistar rats (8 weeks old, 160–180 g)",
  "sample_size": 36,
  "outcomes": [
    "Bone mineral density (BMD) by DEXA",
    "Locomotor activity pattern (metabolism measuring system)",
    "Histological examination of bone tissue (trabecular bone continuity, bone mass)"
  ],
  "main_findings": "In ovariectomized rats, 12-week exposure to a static magnetic field inhibited the reduction in bone mineral density observed in OVX controls without SMF. After SMF exposure, OVX rats showed a more regular, diphasic locomotor activity pattern with clear active/resting phases, and histology indicated more favorable maintenance of trabecular bone continuity and higher bone mass versus OVX controls.",
  "effect_direction": "benefit",
  "limitations": [
    "Magnetic field strength and exposure parameters (beyond duration) not reported in the abstract",
    "Animal model (OVX rats); generalizability to humans not established in the abstract",
    "No details provided on randomization/blinding or statistical methods in the abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "static magnetic field",
    "SMF",
    "osteopenia",
    "ovariectomized rat",
    "bone mineral density",
    "DEXA",
    "locomotor activity",
    "trabecular bone",
    "bone mass"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1093/ecam/nel067
PubMed: 17342247

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