Induction of thrombosis of the abdominal aneurysm sac through the application of radiofrequency. An experimental study.
← Research streamIn six dogs, application of radiofrequency to the aneurysm sac (1 minute; 127 mA ± 33; tip temperature 92°C ± 2) was reported to be effective at inducing thrombosis/blood clotting, assessed by IVUS and histology. The authors suggest this approach could be con…
Study snapshot
Abstract
UNLABELLED: This is an experimental study of endovascular aortic surgery for evaluation of the effect of thrombosis induced in the aneurysmal sac using a radiofrequency method. PURPOSE: To determine the efficacy of the induction of thrombosis of the abdominal aneurysm sac as a prevention of endoleaks after endovascular treatment. MATERIALS AND METHODS: Six dogs underwent radiofrequency blood clotting of the aneurysm sac and where afterwards treated with stent-grafting. A comparison with a historical group of 4 dogs with an abdominal aneurysm treated with stent-grafting was used. Radiofrequency was applied to each sac for 1 minute at 127 mA ± 33 (mean ± SD) (tip temperature, 92°C ± 2). IVUS ultrasonography and histology studies were used for the evaluation of the method. RESULTS: The results show the efficacy of the radiofrequency method and its possible future inclusion as a standard clinical application. DISCUSSION AND CONCLUSIONS: Endovascular repair of abdominal aortic aneurysms is dependent on the complete exclusion of the aneurysm from the arterial circulation. Later growth of the aneurysm is originated from retrograde flow into the sac. This study demonstrates how the use of radiofrequency induced thrombosis in a canine model of aneurysm sac. Ultrasound IVUS enabled further control for assessment of blood coagulation after radiofrequency treatment. This approach may be considered a tool for future prevention of endoleaks, in clinical practice.
AI evidence extraction
Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.
Main findings
In six dogs, application of radiofrequency to the aneurysm sac (1 minute; 127 mA ± 33; tip temperature 92°C ± 2) was reported to be effective at inducing thrombosis/blood clotting, assessed by IVUS and histology. The authors suggest this approach could be considered for future prevention of endoleaks after endovascular repair.
Outcomes measured
- Induction of thrombosis/blood coagulation in aneurysm sac
- Potential prevention of endoleaks after stent-grafting
- IVUS ultrasonography assessment of coagulation
- Histology evaluation
Limitations
- Small sample size (6 treated animals)
- Comparison group described as a historical group (4 dogs) rather than concurrent randomized control
- Radiofrequency parameters reported in current and temperature but not frequency or dosimetry (e.g., SAR)
- Animal model; clinical effectiveness in humans not established in the abstract
View raw extracted JSON
{
"study_type": "animal",
"exposure": {
"band": null,
"source": "radiofrequency (medical/endovascular application)",
"frequency_mhz": null,
"sar_wkg": null,
"duration": "1 minute per sac"
},
"population": "Dogs (canine model of abdominal aortic aneurysm sac)",
"sample_size": 6,
"outcomes": [
"Induction of thrombosis/blood coagulation in aneurysm sac",
"Potential prevention of endoleaks after stent-grafting",
"IVUS ultrasonography assessment of coagulation",
"Histology evaluation"
],
"main_findings": "In six dogs, application of radiofrequency to the aneurysm sac (1 minute; 127 mA ± 33; tip temperature 92°C ± 2) was reported to be effective at inducing thrombosis/blood clotting, assessed by IVUS and histology. The authors suggest this approach could be considered for future prevention of endoleaks after endovascular repair.",
"effect_direction": "benefit",
"limitations": [
"Small sample size (6 treated animals)",
"Comparison group described as a historical group (4 dogs) rather than concurrent randomized control",
"Radiofrequency parameters reported in current and temperature but not frequency or dosimetry (e.g., SAR)",
"Animal model; clinical effectiveness in humans not established in the abstract"
],
"evidence_strength": "very_low",
"confidence": 0.74,
"peer_reviewed_likely": "yes",
"keywords": [
"radiofrequency",
"thrombosis",
"blood coagulation",
"abdominal aortic aneurysm",
"endovascular repair",
"stent-grafting",
"endoleak prevention",
"canine model",
"IVUS",
"histology"
],
"suggested_hubs": [
{
"slug": "engineering",
"weight": 0.32,
"reason": "Radiofrequency used as a procedural method/device application in an endovascular surgical model."
}
]
}AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.
Identifiers and source
DOI: Not supplied
PubMed: 23894740