[Modulation of Ca(2+)-dependent proteinase activity in invertebrates and fish under the action of weak low-frequency magnetic fields].

{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Fish and invertebrates",
  "sample_size": null,
  "outcomes": [
    "Intracellular Ca(2+)-dependent proteinase (calpain) activity"
  ],
  "main_findings": "In in vivo experiments, exposure to a weak low-frequency magnetic field tuned to the parametric resonance for Ca2+ ions was associated with a significant decrease in calpain activity in the examined animals. In in vitro experiments, preparations of Ca(2+)-dependent proteinases from invertebrates and fish were also substantially inactivated under the same factor.",
  "effect_direction": "mixed",
  "limitations": [
    "No quantitative exposure parameters (e.g., frequency, field strength, duration) reported in the abstract.",
    "No sample size or species details provided.",
    "Outcome reporting is qualitative; effect sizes and statistical details are not described.",
    "Unclear experimental design details (controls, blinding, replication) from abstract alone."
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "low-frequency magnetic field",
    "weak magnetic field",
    "ELF",
    "parametric resonance",
    "Ca2+ ions",
    "calpain",
    "Ca(2+)-dependent proteinases",
    "invertebrates",
    "fish",
    "in vivo",
    "in vitro"
  ],
  "suggested_hubs": [
    {
      "slug": "elf-magnetic-fields",
      "weight": 0.9,
      "reason": "Study examines biological effects of weak low-frequency (ELF) magnetic fields."
    },
    {
      "slug": "mechanisms-calcium-signaling",
      "weight": 0.75,
      "reason": "Exposure is tuned to Ca2+ parametric resonance and outcome is Ca2+-dependent protease activity."
    }
  ]
}