Effects of electromagnetic field (1.8/0.9 GHz) exposure on growth plate in growing rats.

Research in veterinary science · 2016 · Mixed · Low evidence

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MixedLow evidencePaper 2973

Study snapshot

PublicationResearch in veterinary science · 2016

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

The purpose of this study was to determine the effects of whole-body electromagnetic field (EMF) exposure on growth plates in growing male rats. Two groups of rats were exposed to either 900 MHz EMF or 1800 MHz EMF 2 h/day for 90 days. Sham control rats were kept under similar conditions without exposure to the EMF. The rats in the EMF group experienced a more rapid weight gain and increase in length (p < 0.05). Calcium, growth hormone, estradiol and testosterone levels in the EMF groups were higher (p < 0.05). The Safranin O staining density of femoral growth plate was lowest in the reserve zone of rats exposed to 1800 MHz and was increased in the proliferative zone of the control group (p < 0.05). The trabecular zone was thinnest among all zones and the reserve and proliferative zones were thicker (p < 0.05) than other zones in 1800 MHz group.In conclusion, 1800 MHz and 900 MHz EMF may cause prolong the growth phase in growing rats.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionmixed

PopulationGrowing male rats

Sample sizeNot supplied

ExposureRF · 2 h/day for 90 days

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Rats exposed whole-body to 900 MHz or 1800 MHz EMF for 2 h/day for 90 days had more rapid weight gain and increased length versus sham controls (p<0.05). Calcium, growth hormone, estradiol, and testosterone levels were higher in EMF-exposed groups (p<0.05), and growth plate staining density and zone thickness differed by exposure group, with the authors concluding EMF exposure may prolong the growth phase in growing rats.

Outcomes measured

Body weight gain
Body length increase
Calcium levels
Growth hormone levels
Estradiol levels
Testosterone levels
Femoral growth plate Safranin O staining density (reserve/proliferative zones)
Growth plate zone thickness (trabecular/reserve/proliferative zones)

Limitations

Sample size not reported in abstract
No SAR/dosimetry details reported in abstract
Only male rats studied
Exposure conditions beyond frequency and duration not detailed in abstract

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": "whole-body EMF exposure",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "2 h/day for 90 days"
  },
  "population": "Growing male rats",
  "sample_size": null,
  "outcomes": [
    "Body weight gain",
    "Body length increase",
    "Calcium levels",
    "Growth hormone levels",
    "Estradiol levels",
    "Testosterone levels",
    "Femoral growth plate Safranin O staining density (reserve/proliferative zones)",
    "Growth plate zone thickness (trabecular/reserve/proliferative zones)"
  ],
  "main_findings": "Rats exposed whole-body to 900 MHz or 1800 MHz EMF for 2 h/day for 90 days had more rapid weight gain and increased length versus sham controls (p<0.05). Calcium, growth hormone, estradiol, and testosterone levels were higher in EMF-exposed groups (p<0.05), and growth plate staining density and zone thickness differed by exposure group, with the authors concluding EMF exposure may prolong the growth phase in growing rats.",
  "effect_direction": "mixed",
  "limitations": [
    "Sample size not reported in abstract",
    "No SAR/dosimetry details reported in abstract",
    "Only male rats studied",
    "Exposure conditions beyond frequency and duration not detailed in abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "radiofrequency",
    "900 MHz",
    "1800 MHz",
    "whole-body exposure",
    "rats",
    "growth plate",
    "growth hormone",
    "sex hormones",
    "Safranin O"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1016/j.rvsc.2015.11.002
PubMed: 26850533

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