Greyscale intravascular ultrasound and IVUS-radiofrequency tissue characterisation to improve understanding of the mechanisms of coronary stent thrombosis in drug-eluting stents.

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2008 · Unclear · Insufficient evidence

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UnclearInsufficient evidencePaper 2812

Study snapshot

PublicationEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2008

Study typereview

Reported directionUnclear

Evidence ratingInsufficient

Abstract

Stent thrombosis is one of the major concerns after drug-eluting stent implantation. Multiple mechanical causes (i.e., stent under-expansion, edge dissection, geographic miss, residual stenosis, incomplete stent apposition and aneurysm) have been postulated. These features are easily identifiable by intravascular ultrasound. However, it is uncertain which of them are inextricably related to stent thrombosis, primarily due to the low number of such patients studied by IVUS in case control studies. Complementary to greyscale IVUS, tissue characterisation by IVUS radiofrequency data (RFD) analysis has the potential to add valuable information on the pathogenesis of stent thrombosis by providing information on plaque composition, specifically on the amount of necrotic core and its location (superficial or deep). However, the clinical utility of IVUS-RFD analysis in this context has yet to be demonstrated.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typereview

Effect directionunclear

PopulationNot supplied

Sample sizeNot supplied

ExposureNot supplied

Evidence strengthInsufficientConfidence: 74% · Peer reviewed: yes

Main findings

The article discusses mechanical features identifiable by intravascular ultrasound that have been postulated as causes of drug-eluting stent thrombosis, but notes uncertainty about which are directly related due to limited case-control IVUS data. It suggests IVUS radiofrequency data analysis may add information on plaque composition (e.g., necrotic core amount and location), while stating that its clinical utility for stent thrombosis has not yet been demonstrated.

Outcomes measured

coronary stent thrombosis mechanisms
intravascular ultrasound (IVUS) identification of mechanical causes
IVUS radiofrequency data (RFD) tissue characterisation (plaque composition/necrotic core)

Limitations

Uncertainty about which IVUS-identified mechanical features are directly related to stent thrombosis due to low numbers of patients studied by IVUS in case-control studies
Clinical utility of IVUS radiofrequency data analysis for stent thrombosis has not yet been demonstrated

View raw extracted JSON

{
  "study_type": "review",
  "exposure": {
    "band": null,
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": null,
  "sample_size": null,
  "outcomes": [
    "coronary stent thrombosis mechanisms",
    "intravascular ultrasound (IVUS) identification of mechanical causes",
    "IVUS radiofrequency data (RFD) tissue characterisation (plaque composition/necrotic core)"
  ],
  "main_findings": "The article discusses mechanical features identifiable by intravascular ultrasound that have been postulated as causes of drug-eluting stent thrombosis, but notes uncertainty about which are directly related due to limited case-control IVUS data. It suggests IVUS radiofrequency data analysis may add information on plaque composition (e.g., necrotic core amount and location), while stating that its clinical utility for stent thrombosis has not yet been demonstrated.",
  "effect_direction": "unclear",
  "limitations": [
    "Uncertainty about which IVUS-identified mechanical features are directly related to stent thrombosis due to low numbers of patients studied by IVUS in case-control studies",
    "Clinical utility of IVUS radiofrequency data analysis for stent thrombosis has not yet been demonstrated"
  ],
  "evidence_strength": "insufficient",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "stent thrombosis",
    "drug-eluting stents",
    "intravascular ultrasound",
    "IVUS",
    "radiofrequency data",
    "tissue characterisation",
    "plaque composition",
    "necrotic core"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 19202689

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