Head-to-head comparison of coronary plaque evaluation between multislice computed tomography and intravascular ultrasound radiofrequency data analysis.

JACC. Cardiovascular interventions · 2008 · Unclear · Insufficient evidence

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UnclearInsufficient evidencePaper 2774

Study snapshot

PublicationJACC. Cardiovascular interventions · 2008

Study typeother

Reported directionUnclear

Evidence ratingInsufficient

Abstract

OBJECTIVES: The purpose of this study was to perform a head-to-head comparison of plaque observations with multislice computed tomography (MSCT) to virtual histology intravascular ultrasound (VH IVUS). BACKGROUND: The VH IVUS allows in vivo coronary plaque characterization with high spatial resolution. Noninvasively, plaques may be evaluated with MSCT, but limited data are available. METHODS: A total of 50 patients underwent 64-slice MSCT followed by VH IVUS. The Agatston score was evaluated on MSCT in coronary segments where IVUS was performed. Plaques were classified on MSCT as noncalcified, mixed, and calcified. Four plaque components (fibrotic, fibro-fatty, and necrotic core tissues and dense calcium) were identified on VH IVUS, and the presence of thin-cap fibroatheroma was evaluated. RESULTS: A moderate correlation was observed between the Agatston score and calcium volume on VH IVUS (r = 0.69, p < 0.0001). In total, 168 coronary plaques were evaluated (48 [29%] noncalcified, 71 [42%] mixed, 49 [29%] calcified). As compared with calcified plaques, noncalcified plaques contained more fibrotic (60.90 +/- 9.21% vs. 54.60 +/- 8.33%, p = 0.001) and fibro-fatty tissues (28.11 +/- 13.03% vs. 21.37 +/- 9.75%, p = 0.006) on VH IVUS. Mixed and calcified plaques contained more dense calcium (7.61 +/- 8.94% vs. 2.68 +/- 3.01%, p = 0.001; 10.18 +/- 6.71% vs. 2.68 +/- 3.01%, p < 0.0001, respectively). Thin-cap fibroatheromas were most frequently observed in mixed plaques as compared with noncalcified and calcified plaques (32%, 13%, 8%, p = 0.002, respectively). CONCLUSIONS: A good correlation was observed between calcium quantification on MSCT and VH IVUS. In addition, plaque classification on MSCT paralleled relative plaque composition on VH IVUS, although VH IVUS provided more precise plaque characterization. Mixed plaques on MSCT were associated with high-risk features on VH IVUS.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeother

Effect directionunclear

PopulationPatients undergoing coronary imaging (64-slice multislice computed tomography followed by virtual histology intravascular ultrasound).

Sample size50

ExposureNot supplied

Evidence strengthInsufficientConfidence: 74% · Peer reviewed: yes

Main findings

In 50 patients (168 plaques), Agatston score on MSCT moderately correlated with calcium volume on VH IVUS (r=0.69, p<0.0001). Noncalcified plaques had higher fibrotic and fibro-fatty tissue percentages than calcified plaques, while mixed and calcified plaques had higher dense calcium. Thin-cap fibroatheromas were most frequent in mixed plaques (32%) compared with noncalcified (13%) and calcified (8%) plaques.

Outcomes measured

Correlation between Agatston score (MSCT) and calcium volume (VH IVUS)
MSCT plaque classification (noncalcified, mixed, calcified) vs VH IVUS plaque composition (fibrotic, fibro-fatty, necrotic core, dense calcium)
Presence of thin-cap fibroatheroma across MSCT plaque classes

View raw extracted JSON

{
  "study_type": "other",
  "exposure": {
    "band": null,
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Patients undergoing coronary imaging (64-slice multislice computed tomography followed by virtual histology intravascular ultrasound).",
  "sample_size": 50,
  "outcomes": [
    "Correlation between Agatston score (MSCT) and calcium volume (VH IVUS)",
    "MSCT plaque classification (noncalcified, mixed, calcified) vs VH IVUS plaque composition (fibrotic, fibro-fatty, necrotic core, dense calcium)",
    "Presence of thin-cap fibroatheroma across MSCT plaque classes"
  ],
  "main_findings": "In 50 patients (168 plaques), Agatston score on MSCT moderately correlated with calcium volume on VH IVUS (r=0.69, p<0.0001). Noncalcified plaques had higher fibrotic and fibro-fatty tissue percentages than calcified plaques, while mixed and calcified plaques had higher dense calcium. Thin-cap fibroatheromas were most frequent in mixed plaques (32%) compared with noncalcified (13%) and calcified (8%) plaques.",
  "effect_direction": "unclear",
  "limitations": [],
  "evidence_strength": "insufficient",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "multislice computed tomography",
    "MSCT",
    "64-slice CT",
    "virtual histology",
    "intravascular ultrasound",
    "VH IVUS",
    "coronary plaque",
    "Agatston score",
    "thin-cap fibroatheroma"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1016/j.jcin.2008.01.007
PubMed: 19463297

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