Effect of the radiation emitted from a cell phone on T lymphocytes in mice

Radiation Effects and Defects in Solids · 2025 · Harm · Low evidence

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HarmLow evidencePaper 2589

Study snapshot

PublicationRadiation Effects and Defects in Solids · 2025

Study typeanimal

Reported directionHarm

Evidence ratingLow

Abstract

Category: Immunology, Radiation Biology Tags: cell phone radiation, T lymphocytes, mouse study, apoptosis, cytokines, IL-10, IL-12 DOI: 10.1080/10420150.2025.2526402 URL: tandfonline.com Overview This present study aims to explore the potential impact of cell phone radiation on T lymphocytes in mice. One hundred twenty-eight healthy male BALB/C mice (2-3 weeks old) were randomly distributed into four groups: blank control, control, TD-SCDMA and LTE-Advanced groups, with 32 mice in each group. Mice were exposed to phone radiation for 2-8 weeks and evaluated at four time points (2, 4, 6, and 8 weeks). Methods - Flow cytometry was performed to examine T lymphocyte subsets. - Molecular and cell biological techniques were carried out to detect apoptosis and transformation of T lymphocytes. - Enzyme-labelled immune technique was conducted to measure cytokines secreted by T lymphocytes. Findings - Percentages of CD4 and CD8 T lymphocyte subsets were similar among all groups throughout the exposure period. - After more than six weeks of exposure to TD-SCDMA and LTE-Advanced radiation, the apoptosis ratios of T lymphocytes significantly increased compared to shams, while transformation rates decreased significantly. - The impacts of radiation on apoptosis and transformation were found to be time-dependent. - The concentrations of IL-10 and IL-12 were unchanged in the control groups. In the exposure groups, IL-10 concentrations decreased significantly and IL-12 concentrations increased statistically. The decrease in IL-10 lagged behind the increase in IL-12. Conclusion Radiation from mobile phones resulted in T lymphocyte injury, with the adverse effect becoming more severe with prolonged radiation exposure. Cell phone radiation suppressed the secretion of IL-10 and enhanced the production of IL-12 in T lymphocytes. ⚠️ EMF Link: This study demonstrates a clear connection between cell phone electromagnetic radiation and negative immunological effects, such as increased T lymphocyte apoptosis and cytokine imbalance in mice.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionharm

PopulationHealthy male BALB/C mice (2–3 weeks old)

Sample size128

ExposureRF · 2–8 weeks (assessed at 2, 4, 6, 8 weeks)

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

In 128 male BALB/C mice randomized to blank control, control, TD-SCDMA, and LTE-Advanced groups (32/group), CD4 and CD8 T-lymphocyte subset percentages were similar across groups throughout 2–8 weeks. After more than 6 weeks of TD-SCDMA or LTE-Advanced exposure, T-lymphocyte apoptosis increased and transformation rates decreased versus shams, with time-dependent effects. In exposure groups, IL-10 decreased significantly and IL-12 increased statistically, while control groups showed no change.

Outcomes measured

CD4 T lymphocyte percentage
CD8 T lymphocyte percentage
T lymphocyte apoptosis
T lymphocyte transformation rate
IL-10 concentration
IL-12 concentration

Limitations

Exposure parameters (e.g., frequency, SAR, power density) not reported in the abstract
Animal model (mice) limits direct generalizability to humans
Sham/control condition details not fully described in the abstract

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": "mobile phone",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "2–8 weeks (assessed at 2, 4, 6, 8 weeks)"
  },
  "population": "Healthy male BALB/C mice (2–3 weeks old)",
  "sample_size": 128,
  "outcomes": [
    "CD4 T lymphocyte percentage",
    "CD8 T lymphocyte percentage",
    "T lymphocyte apoptosis",
    "T lymphocyte transformation rate",
    "IL-10 concentration",
    "IL-12 concentration"
  ],
  "main_findings": "In 128 male BALB/C mice randomized to blank control, control, TD-SCDMA, and LTE-Advanced groups (32/group), CD4 and CD8 T-lymphocyte subset percentages were similar across groups throughout 2–8 weeks. After more than 6 weeks of TD-SCDMA or LTE-Advanced exposure, T-lymphocyte apoptosis increased and transformation rates decreased versus shams, with time-dependent effects. In exposure groups, IL-10 decreased significantly and IL-12 increased statistically, while control groups showed no change.",
  "effect_direction": "harm",
  "limitations": [
    "Exposure parameters (e.g., frequency, SAR, power density) not reported in the abstract",
    "Animal model (mice) limits direct generalizability to humans",
    "Sham/control condition details not fully described in the abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "cell phone radiation",
    "mobile phone",
    "RF",
    "TD-SCDMA",
    "LTE-Advanced",
    "mice",
    "BALB/C",
    "T lymphocytes",
    "CD4",
    "CD8",
    "apoptosis",
    "cytokines",
    "IL-10",
    "IL-12",
    "immunology"
  ],
  "suggested_hubs": [
    {
      "slug": "animal-studies",
      "weight": 0.9,
      "reason": "Mouse experiment assessing immunological outcomes after mobile phone radiation exposure"
    },
    {
      "slug": "mobile-phones",
      "weight": 0.85,
      "reason": "Exposure source is cell phone radiation (TD-SCDMA, LTE-Advanced)"
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1080/10420150.2025.2526402
PubMed: Not supplied

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