Dosimetric Assessment for Mice & Rats Exposed in Reverberation Chambers for the Two-Year NTP Cancer Bioassay Study on Cell Phone Radiation

2017 · Unclear · Insufficient evidence

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UnclearInsufficient evidencePaper 2340

Study snapshot

Publicationmanual · 2017

Study typeexposure_assessment

Reported directionUnclear

Evidence ratingInsufficient

Abstract

Dosimetric Assessment for Mice & Rats Exposed in Reverberation Chambers for the Two-Year NTP Cancer Bioassay Study on Cell Phone Radiation Gong, YJ, Capstick, MH; Kuehn, S ; Wilson, PF; Ladbury, JM ; Koepke, G; McCormick, DL ; Melnick, RL Kuster, N.Life-Time Dosimetric Assessment for Mice and Rats Exposed in Reverberation Chambers for the Two-Year NTP Cancer Bioassay Study on Cell Phone Radiation. IEEE Transactions on Electromagnetic Compatibility. 59(6):1798- 1808. DOI: 10.1109/TEMC.2017.2665039. Dec 2017. Abstract In this paper, we present the detailed life-time dosimetry analysis for rodents exposed in the reverberation exposure system designed for the two-year cancer bioassay study conducted by the National Toxicology Program of the National Institute of Environmental Health Sciences. The study required the well-controlled and characterized exposure of individually housed, unrestrained mice at 1900 MHz and rats at 900 MHz, frequencies chosen to give best uniformity exposure of organs and tissues. The wbSAR, the peak spatial SAR, and the organ specific SAR as well as the uncertainty and variation due to the exposure environment, differences in the growth rates, and animal posture were assessed. Compared to the wbSAR, the average exposure of the high-water- content tissues (blood, heart, lung) were higher by similar to 4 dB, while the low-loss tissues (bone and fat) were less by similar to 9 dB. The maximum uncertainty over the exposure period for the SAR was estimated to be <49% (k = 2) for the rodents whereas the relative uncertainty between the exposure groups was < 14% (k = 1). The instantaneous variation (averaged over 1 min) was < 13% (k = 1), which is small compared to other long term exposure research projects. These detailed dosimetric results empowers comparison with other studies and provides a reference for studies of long-term biological effects of exposure. ieeexplore.ieee.org

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeexposure_assessment

Effect directionunclear

PopulationRodents (individually housed, unrestrained mice and rats)

Sample sizeNot supplied

ExposureRF · life-time dosimetry analysis for a two-year cancer bioassay study

Evidence strengthInsufficientConfidence: 78% · Peer reviewed: yes

Main findings

The paper reports life-time dosimetry for rodents in a reverberation exposure system used for a two-year NTP cancer bioassay: mice were exposed at 1900 MHz and rats at 900 MHz. Relative to wbSAR, average SAR in high-water-content tissues (blood, heart, lung) was higher by ~4 dB, while low-loss tissues (bone, fat) were lower by ~9 dB. Maximum uncertainty over the exposure period for SAR was estimated as <49% (k=2) and relative uncertainty between exposure groups as <14% (k=1); instantaneous (1 min) variation was <13% (k=1).

Outcomes measured

Whole-body SAR (wbSAR)
Peak spatial SAR
Organ-specific SAR
Uncertainty and variation in SAR over exposure period
Instantaneous (1 min averaged) SAR variation
Differences in SAR by tissue type (high-water-content vs low-loss tissues)

View raw extracted JSON

{
  "study_type": "exposure_assessment",
  "exposure": {
    "band": "RF",
    "source": "mobile phone",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "life-time dosimetry analysis for a two-year cancer bioassay study"
  },
  "population": "Rodents (individually housed, unrestrained mice and rats)",
  "sample_size": null,
  "outcomes": [
    "Whole-body SAR (wbSAR)",
    "Peak spatial SAR",
    "Organ-specific SAR",
    "Uncertainty and variation in SAR over exposure period",
    "Instantaneous (1 min averaged) SAR variation",
    "Differences in SAR by tissue type (high-water-content vs low-loss tissues)"
  ],
  "main_findings": "The paper reports life-time dosimetry for rodents in a reverberation exposure system used for a two-year NTP cancer bioassay: mice were exposed at 1900 MHz and rats at 900 MHz. Relative to wbSAR, average SAR in high-water-content tissues (blood, heart, lung) was higher by ~4 dB, while low-loss tissues (bone, fat) were lower by ~9 dB. Maximum uncertainty over the exposure period for SAR was estimated as <49% (k=2) and relative uncertainty between exposure groups as <14% (k=1); instantaneous (1 min) variation was <13% (k=1).",
  "effect_direction": "unclear",
  "limitations": [],
  "evidence_strength": "insufficient",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "dosimetry",
    "reverberation chamber",
    "rodents",
    "mice",
    "rats",
    "NTP",
    "National Toxicology Program",
    "cell phone radiation",
    "RF exposure",
    "SAR",
    "whole-body SAR",
    "organ-specific SAR",
    "1900 MHz",
    "900 MHz",
    "uncertainty",
    "variation"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1109/temc.2017.2665039
PubMed: Not supplied

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