RF Safe

Adaptive Response Induced by Pre-Exposure to 915 MHz RF: A Possible Role for Antioxidant Enzyme Activity

2017 · Benefit · Low evidence

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BenefitLow evidencePaper 2239

In rat liver, pre-exposure to 915 MHz RF at specific power levels was reported to induce an adaptive response associated with changes in antioxidant balance. Increases in GSH and GR activity were mainly observed in the low-power RF group, with GR activity als…

Study snapshot

Publicationmanual · 2017
Study typeanimal
Reported directionBenefit
Evidence ratingLow

Abstract

Adaptive Response Induced by Pre-Exposure to 915 MHz RF: A Possible Role for Antioxidant Enzyme Activity Mortazavi SMJ, Mostafavi-Pour Z, Daneshmand M, Zal F, Zare R, Mosleh-Shirazi MA. Adaptive Response Induced by Pre-Exposure to 915 MHz Radiofrequency: A Possible Role for Antioxidant Enzyme Activity. J Biomed Phys Eng. 2017 Jun 1;7(2):137-142. Abstract BACKGROUND: Over the past few years, the rapid use of high frequency electromagnetic fields like mobile phones has raised global concerns about the negative health effects of its use. Adaptive response is the ability of a cell or tissue to better resist stress damage by prior exposure to a lesser amount of stress. This study aimed to assess whether radiofrequency radiation can induce adaptive response by changing the antioxidant balance. MATERIALS AND METHODS: In order to assess RF-induced adaptive response in tissues, we evaluated the level of GSH and the activity of GR in liver. 50 rats were divided into 5 groups. Three groups were pre-exposed to 915 MHz RF radiation, 4 hours per day for one week at different powers, as low, medium and high. 24 hours after the last exposure to radiation, they were exposed to 4 Gy sublethal dose of gamma radiation and then sacrificed after 5 hours. Their livers were removed, washed and were kept at -80o C until used. RESULTS: Our finding showed that pre-exposure to 915 MHz radiofrequency radiation with specific power could induce adaptive response in liver by inducing changes in the activity and level of antioxidant enzymes. CONCLUSION: It can be concluded that pre-exposure to microwave radiation could increase the level of GSH and the activity of GR enzyme, although these increases were seen just in low power group, and the GR activity was indicated in medium power group. This increase protects tissue from oxidative damage induced by sublethal dose of gamma radiation. ncbi.nlm.nih.gov

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionbenefit
PopulationRats (liver tissue assessed)
Sample size50
ExposureRF · 915 MHz · 4 hours/day for 1 week (pre-exposure); gamma challenge 24 hours after last RF exposure; sacrificed 5 hours after gamma
Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

In rat liver, pre-exposure to 915 MHz RF at specific power levels was reported to induce an adaptive response associated with changes in antioxidant balance. Increases in GSH and GR activity were mainly observed in the low-power RF group, with GR activity also indicated in the medium-power group, and were interpreted as protective against oxidative damage from a subsequent 4 Gy gamma radiation exposure.

Outcomes measured

  • Liver glutathione (GSH) level
  • Liver glutathione reductase (GR) activity
  • Adaptive response to 4 Gy gamma radiation (oxidative damage protection inferred)

Limitations

  • Power levels for low/medium/high RF exposure not specified in the abstract
  • No SAR or dosimetry details reported in the abstract
  • Outcome measures limited to GSH and GR in liver; broader health outcomes not assessed
  • Details of statistical analysis and magnitude of effects not provided in the abstract
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": null,
    "frequency_mhz": 915,
    "sar_wkg": null,
    "duration": "4 hours/day for 1 week (pre-exposure); gamma challenge 24 hours after last RF exposure; sacrificed 5 hours after gamma"
  },
  "population": "Rats (liver tissue assessed)",
  "sample_size": 50,
  "outcomes": [
    "Liver glutathione (GSH) level",
    "Liver glutathione reductase (GR) activity",
    "Adaptive response to 4 Gy gamma radiation (oxidative damage protection inferred)"
  ],
  "main_findings": "In rat liver, pre-exposure to 915 MHz RF at specific power levels was reported to induce an adaptive response associated with changes in antioxidant balance. Increases in GSH and GR activity were mainly observed in the low-power RF group, with GR activity also indicated in the medium-power group, and were interpreted as protective against oxidative damage from a subsequent 4 Gy gamma radiation exposure.",
  "effect_direction": "benefit",
  "limitations": [
    "Power levels for low/medium/high RF exposure not specified in the abstract",
    "No SAR or dosimetry details reported in the abstract",
    "Outcome measures limited to GSH and GR in liver; broader health outcomes not assessed",
    "Details of statistical analysis and magnitude of effects not provided in the abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "915 MHz",
    "radiofrequency",
    "microwave radiation",
    "adaptive response",
    "pre-exposure",
    "rats",
    "liver",
    "glutathione",
    "GSH",
    "glutathione reductase",
    "GR",
    "antioxidant enzymes",
    "gamma radiation",
    "oxidative damage"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: Not supplied

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