ELF MF and Redox-Responsive Pathways Linked to Cancer Drug Resistance: Insights from Co-Exposure-Based In Vitro Studies

2018 · Unclear · Insufficient evidence

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UnclearInsufficient evidencePaper 2161

This review discusses in vitro co-exposure studies examining whether ELF magnetic fields, together with reactive oxygen species-generating agents, may modulate redox-responsive mediators and cytoprotective networks in tumor/cancer cells in ways potentially re…

Study snapshot

Publicationmanual · 2018

Study typereview

Reported directionUnclear

Evidence ratingInsufficient

Abstract

ELF MF and Redox-Responsive Pathways Linked to Cancer Drug Resistance: Insights from Co-Exposure-Based In Vitro Studies Falone S, Santini S, Cordone V, Di Emidio G, Tatone C, Caachio M, Amicarelli F. Extremely Low-Frequency Magnetic Fields and Redox-Responsive Pathways Linked to Cancer Drug Resistance: Insights from Co-Exposure- Based In Vitro Studies. 23 Feb 2018. doi.org Electrical devices currently used in clinical practice and common household equipments generate extremely low-frequency magnetic fields (ELF-MF) that were classified by the International Agency for Research on Cancer as "possible carcinogenic." Assuming that ELF-MF plays a role in the carcinogenic process without inducing direct genomic alterations, ELF-MF may be involved in the promotion or progression of cancers. In particular, ELF-MF-induced responses are suspected to activate redox-responsive intracellular signaling or detoxification scavenging systems. In fact, improved protection against oxidative stress and redox-active xenobiotics is thought to provide critical proliferative and survival advantage in tumors. On this basis, an ever-growing research activity worldwide is attempting to establish whether tumor cells may develop multidrug resistance through the activation of essential cytoprotective networks in the presence of ELF fields, and how this might trigger relevant changes in tumor phenotype. This review builds a framework around how the activity of redox-responsive mediators may be controlled by co-exposure to ELF-MF and reactive oxygen species-generating agents in tumor and cancer cells, in order to clarify whether and how such potential molecular targets could help to minimize or neutralize the functional interaction between ELF-MF and malignancies. Open Access Paper: frontiersin.org

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typereview

Effect directionunclear

PopulationNot supplied

Sample sizeNot supplied

ExposureELF

Evidence strengthInsufficientConfidence: 66% · Peer reviewed: unknown

Main findings

Outcomes measured

Redox-responsive intracellular signaling
Detoxification/scavenging systems
Oxidative stress protection
Tumor cell multidrug resistance (cancer drug resistance)
Tumor phenotype changes (potential)

Limitations

Narrative review; no specific study selection methods or quantitative synthesis described in the abstract
Mechanistic hypotheses discussed; no explicit causal conclusions or effect sizes reported in the abstract
Exposure parameters (frequency/field strength/duration) not specified in the abstract

View raw extracted JSON

{
  "study_type": "review",
  "exposure": {
    "band": "ELF",
    "source": "electrical devices (clinical practice) and common household equipment",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": null,
  "sample_size": null,
  "outcomes": [
    "Redox-responsive intracellular signaling",
    "Detoxification/scavenging systems",
    "Oxidative stress protection",
    "Tumor cell multidrug resistance (cancer drug resistance)",
    "Tumor phenotype changes (potential)"
  ],
  "main_findings": "This review discusses in vitro co-exposure studies examining whether ELF magnetic fields, together with reactive oxygen species-generating agents, may modulate redox-responsive mediators and cytoprotective networks in tumor/cancer cells in ways potentially relevant to cancer progression and multidrug resistance.",
  "effect_direction": "unclear",
  "limitations": [
    "Narrative review; no specific study selection methods or quantitative synthesis described in the abstract",
    "Mechanistic hypotheses discussed; no explicit causal conclusions or effect sizes reported in the abstract",
    "Exposure parameters (frequency/field strength/duration) not specified in the abstract"
  ],
  "evidence_strength": "insufficient",
  "confidence": 0.66,
  "peer_reviewed_likely": "unknown",
  "keywords": [
    "extremely low-frequency magnetic fields",
    "ELF-MF",
    "redox-responsive pathways",
    "oxidative stress",
    "reactive oxygen species",
    "cancer",
    "multidrug resistance",
    "in vitro",
    "co-exposure"
  ],
  "suggested_hubs": [
    {
      "slug": "who-icnirp",
      "weight": 0.25,
      "reason": "Mentions IARC classification of ELF-MF as 'possible carcinogenic' (contextual policy/classification reference)."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.3389/fpubh.2018.00033
PubMed: Not supplied

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